EFSA Compendium of Botanicals

Draft - work in progress

Cinchona officinalis L.

Family:: Rubiaceae
Approval state:: Approved
Number of articles retrieved:: 64
Number of processed references:: 1

Compositions

#1: quinidine #2: cinchonine #3: cinchonidine #4: quinine

Endpoint Studies

Genotoxicity

Composition #1: Ravishankara, MN., Shrivastava, N., Padh, H., Rajani, M. HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. PLANTA MEDICA, 2001, vol. 67, no. 3, p. 294–296. DOI: 10.1055/s-2001-11995. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ammonium solution and carboxy methyl cellulose
Substance:

quinidine (RF-00004021-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quinidine

Composition #2: Ravishankara, MN., Shrivastava, N., Padh, H., Rajani, M. HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. PLANTA MEDICA, 2001, vol. 67, no. 3, p. 294–296. DOI: 10.1055/s-2001-11995. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ammonium solution and carboxy methyl cellulose
Substance:

cinchonine (RF-00003741-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cinchonine

Composition #3: Ravishankara, MN., Shrivastava, N., Padh, H., Rajani, M. HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. PLANTA MEDICA, 2001, vol. 67, no. 3, p. 294–296. DOI: 10.1055/s-2001-11995. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ammonium solution and carboxy methyl cellulose
Substance:

cinchonidine (RF-00003740-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cinchonidine

Composition #4: Ravishankara, MN., Shrivastava, N., Padh, H., Rajani, M. HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations. PLANTA MEDICA, 2001, vol. 67, no. 3, p. 294–296. DOI: 10.1055/s-2001-11995. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ammonium solution and carboxy methyl cellulose
Substance:

quinine (RF-00004022-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quinine