EFSA Compendium of Botanicals

Draft - work in progress

Mondia whitei (Hook.f.) Skeels // Chlorocodon whiteii Hook.f.

Family:: Apocyanaceae
Approval state:: Approved
Number of articles retrieved:: 81
Number of processed references:: 4

Compositions

#1: methylsalicylate #2: 5-chloropropacin (coumarins) #3: propacin (coumarins) #4: fraxetin (coumarins) #5: 5´-methoxypropacin (coumarins) #6: scopoletin (coumarins)

Endpoint Studies

#1: reversible antispermatogenic and antifertility activities #2: androgenic effect

Genotoxicity

Composition #1: Chen, Yung-Wu., Chen, Hsin-Chun., Kuo, Xhao-Kai., Chang, Long-Zen. Volatile Flavor Compounds in Mondia whitei. Journal of the Taiwan Society for Horticultural Science, 2009, vol. 55, no. 1, p. 55–62. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

methylsalicylate

Composition #2: Patnam, R., Kadali, SS., Koumaglo, KH., Roy, R. A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. PHYTOCHEMISTRY, 2005, vol. 66, no. 6, p. 683–686. DOI: 10.1016/j.phytochem.2004.11.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

5-chloropropacin (RF-00004489-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>0.001
Internal remarks:

5-chloropropacin (coumarins)

Composition #3: Patnam, R., Kadali, SS., Koumaglo, KH., Roy, R. A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. PHYTOCHEMISTRY, 2005, vol. 66, no. 6, p. 683–686. DOI: 10.1016/j.phytochem.2004.11.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

propacin (RF-00010997-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>0.012
Internal remarks:

propacin (coumarins)

Composition #4: Patnam, R., Kadali, SS., Koumaglo, KH., Roy, R. A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. PHYTOCHEMISTRY, 2005, vol. 66, no. 6, p. 683–686. DOI: 10.1016/j.phytochem.2004.11.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Fraxetin (RF-00010996-PAR)
Additional substance description:

6-methoxy-7,8-dihydroxycoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>0.022
Internal remarks:

fraxetin (coumarins)

Composition #5: Patnam, R., Kadali, SS., Koumaglo, KH., Roy, R. A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. PHYTOCHEMISTRY, 2005, vol. 66, no. 6, p. 683–686. DOI: 10.1016/j.phytochem.2004.11.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

5´-methoxypropacin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>0.006
Internal remarks:

5´-methoxypropacin (coumarins)

Composition #6: Patnam, R., Kadali, SS., Koumaglo, KH., Roy, R. A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. PHYTOCHEMISTRY, 2005, vol. 66, no. 6, p. 683–686. DOI: 10.1016/j.phytochem.2004.11.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

scopoletin (RF-00004048-PAR)
Additional substance description:

6-methoxy-7-hydroxycoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>0.098
Internal remarks:

scopoletin (coumarins)

Endpoint study #1: Watcho, P., Kamtchouing, P., Sokeng, S., Moundipa, PF., Tantchou, J., Essame, JL., Koueta, N. Reversible antispermatogenic and antifertility activities of Mondia whitei L. in male albino rat. PHYTOTHERAPY RESEARCH, 2001, vol. 15, no. 1, p. 26–29. DOI: 10.1002/1099-1573(200102)15:1<26::AID-PTR679>3.0.CO;2-N. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

55.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

11
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

400
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

testicular lesions resulting in the cessation of spermatogenesis, degenerative changes in the seminiferous tubules and epididymides
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

reversible antispermatogenic and antifertility activities

Endpoint study #2: Watcho, P., Kamtchouing, P., Sokeng, SD., Moundipa, PF., Tantchou, J., Essame, JL., Koueta, N. Androgenic effect of Mondia whitei roots in male rats. ASIAN JOURNAL OF ANDROLOGY, 2004, vol. 6, no. 3, p. 269–272. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

8.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

28
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

ENDOCRINE (TOX12A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

androgenic effect