EFSA Compendium of Botanicals

Draft - work in progress

Cheilocostus speciosus (J.König) C.Specht // Costus speciosus (J.König) Sm.

Family:: Costaceae
Approval state:: Approved
Number of articles retrieved:: 445
Number of processed references:: 6

Compositions

#1: 1,8-cineole #2: Saponins #3: Alkaloids #4: saponins #5: saponins #6: costunolide

Endpoint Studies

#1: Inhibiton of implantation in pregnant rats.

Genotoxicity

Composition #1: Sharma, M. L., Nigam, M. C., Hande, K. L. Essential oil of Costus speciosus. perfumery and essential oil record, 1963, p. 579–580. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.7
Internal remarks:

1,8-cineole

Composition #2: Gunatilaka, A. A. L., Sotheeswaran, S., Balasubramaniam, S. Economically useful plants of Sri Lanka. II. Commercially important steroidal sapogenins from Sri Lanka plants. Journal of the National Science Council of Sri Lanka, 1978, p. 121–128. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

rectified spirit
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Chromatographic tests (F015A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.7-2.5
Internal remarks:

Saponins

Composition #3: Dadsena, Rakesh., Sahu, Nitish Kumar., Agrwal, Shirish., Kumar, Anil. Phytochemical analysis of three endangered plants (Costus specious, Gloriossa superba Linn and Rauvolfia serpentine (Linn) Benth) from Kanker district of Chhattisgarh, India. Bioscan, 2013, p. 655–659. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, methanol, chloroform and petroleum ether
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #4: Dadsena, Rakesh., Sahu, Nitish Kumar., Agrwal, Shirish., Kumar, Anil. Phytochemical analysis of three endangered plants (Costus specious, Gloriossa superba Linn and Rauvolfia serpentine (Linn) Benth) from Kanker district of Chhattisgarh, India. Bioscan, 2013, p. 655–659. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, methanol, chloroform and petroleum ether
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #5: Meagher, LP., Smith, BL., Wilkins, AL. Metabolism of diosgenin-derived saponins: implications for hepatogenous photosensitization diseases in ruminants. ANIMAL FEED SCIENCE AND TECHNOLOGY, 2001, vol. 91, no. 3-4, p. 157–170. DOI: 10.1016/S0377-8401(01)00223-1. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

diosgenin-derived saponins
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

Electospray mass spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #6: Eliza, James., Daisy, Pitchai., Ignacimuthu, Savarimuthu., Duraipandiyan, Veeramuthu. Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats. CHEMICO-BIOLOGICAL INTERACTIONS, 2009, vol. 179, no. 2-3, p. 329–334. DOI: 10.1016/j.cbi.2008.10.017. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane extract
Substance:

costunolide (RF-00003753-PAR)
Analytical method - additional description:

X-ray crystallography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide

Endpoint study #1: Tewari, P. V., Chaturvedi, C., Pandey, V. B. Antifertility activity of Costus speciosus. indian journal of pharmacy, 1973, p. 114–115. .

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Female
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

Prevented implantation in 8 of 10 rats when fed on days 1-7 of pregnancy
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Inhibiton of implantation in pregnant rats.