EFSA Compendium of Botanicals

Draft - work in progress

Ceratocephala testiculata (Crantz) Besser // Ranunculus testiculatus Crantz

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 1
Number of processed references:: 1

Compositions

Endpoint Studies

Genotoxicity

Composition #1: NACHMAN, RJ., OLSEN, JD. RANUNCULIN - A TOXIC CONSTITUENT OF THE POISONOUS RANGE PLANT BUR BUTTERCUP (CERATOCEPHALUS-TESTICULATUS) . journal of agricultural and food chemistry, 1983, vol. 31, no. 6, p. 1358–1360. DOI: 10.1021/jf00120a052. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

ranunculin (RF-00011193-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

C-NMR, H-NMR, IR
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

ranunculin

Composition #2: NACHMAN, RJ., OLSEN, JD. RANUNCULIN - A TOXIC CONSTITUENT OF THE POISONOUS RANGE PLANT BUR BUTTERCUP (CERATOCEPHALUS-TESTICULATUS) . journal of agricultural and food chemistry, 1983, vol. 31, no. 6, p. 1358–1360. DOI: 10.1021/jf00120a052. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

ranunculin (RF-00011193-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

C-NMR, H-NMR, IR
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3
Internal remarks:

ranunculin

Endpoint study #1: NACHMAN, RJ., OLSEN, JD. RANUNCULIN - A TOXIC CONSTITUENT OF THE POISONOUS RANGE PLANT BUR BUTTERCUP (CERATOCEPHALUS-TESTICULATUS) . journal of agricultural and food chemistry, 1983, vol. 31, no. 6, p. 1358–1360. DOI: 10.1021/jf00120a052. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Lowest lethal dose (CHD025EP)
Concentration unit:

Gram (G148A)
Effect concentration:

11
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

labored breathing, post-mortem congestion of the heart
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

pulmonary and cardiac

Endpoint study #2: NACHMAN, RJ., OLSEN, JD. RANUNCULIN - A TOXIC CONSTITUENT OF THE POISONOUS RANGE PLANT BUR BUTTERCUP (CERATOCEPHALUS-TESTICULATUS) . journal of agricultural and food chemistry, 1983, vol. 31, no. 6, p. 1358–1360. DOI: 10.1021/jf00120a052. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Lowest lethal dose (CHD025EP)
Concentration unit:

Gram (G148A)
Effect concentration:

11
Critical effect:

Digestive (TOX18A)
Effect description:

anorexia, diarrhoea, inflammation and oedema in the rumen
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

digestive