EFSA Compendium of Botanicals

Draft - work in progress

Centipeda minima (L.) A.Braun & Asch

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 318
Number of processed references:: 5

Compositions

#1: 6-O-Angeloylenolin (sesquiterpene lactone) #2: Artemisia ketone #3: furan derivatives #4: pinoresinol #5: sesquiterpene lactones #6: Triterpene saponins

Endpoint Studies

Genotoxicity

Composition #1: Changlong, Li., Hezhen, Wu., Yongping, Huang., Yanfang, Yang., Yanwen, Liu., Jianwen, Liu. 6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-kappaB pathway in human leukemia HL60 cells. . biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 2008, vol. 62, no. 6, p. 401–9. DOI: 10.1016/j.biopha.2007.10.010. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

6-O-Angeloylenolin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

6-O-Angeloylenolin (sesquiterpene lactone)

Composition #2: Soetardjo, Surjani Jr., Jong, Poh Chan., Ahmad, Mohamad Noor., Lachimanan, Yoga Latha., Sreenivasan, Sasidharan. Chemical Composition and Biological Activity of the Centipeda minima (Asteraceae). . malaysian journal of nutrition, 2007, vol. 13, no. 1, p. 81–7. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chlorform
Substance:

artemisia ketone (RF-00004157-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.98
Internal remarks:

Artemisia ketone

Composition #3: Soetardjo, Surjani Jr., Jong, Poh Chan., Ahmad, Mohamad Noor., Lachimanan, Yoga Latha., Sreenivasan, Sasidharan. Chemical Composition and Biological Activity of the Centipeda minima (Asteraceae). . malaysian journal of nutrition, 2007, vol. 13, no. 1, p. 81–7. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chlorform
Substance:

furan derivatives (RF-00004396-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

furan derivatives

Composition #4: Cao, Junling., Li, Guohui. Chemical constituents of Centipeda minima .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2012, vol. 37, no. 15, p. 2301–3. .[abstract]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate extract
Substance:

Pinoresinol (RF-00011088-PAR)
Additional substance description:

epipinoresinol
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pinoresinol

Composition #5: Huang, Xuedan., Awano, Yurika., Maeda, Eri., Asada, Yoshihisa., Takemoto, Hiroaki., Watanabe, Takashi., Kojima-Yuasa, Akiko., Kobayashi, Yoshinori. Cytotoxic activity of two natural sesquiterpene lactones, isobutyroylplenolin and arnicolide D, on human colon cancer cell line HT-29 . natural product research, 2014, vol. 28, no. 12, p. 914–916. DOI: 10.1080/14786419.2014.889133. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate extraction
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

arnicolide D, isobutyroylplenolin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactones

Composition #6: GUPTA, D., SINGH, J. TRITERPENOID SAPONINS FROM CENTIPEDA-MINIMA. PHYTOCHEMISTRY, 1989, vol. 28, no. 4, p. 1197–1201. DOI: 10.1016/0031-9422(89)80208-0. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins