EFSA Compendium of Botanicals

Draft - work in progress

Cedrus libani A.Rich.

Family:: Pinaceae
Approval state:: Approved
Number of articles retrieved:: 355
Number of processed references:: 4

Compositions

#1: Tannins (condensed) #2: myrcene #3: Lignans

Endpoint Studies

Genotoxicity

Composition #1: Karabulut, A., Canbolat, O., Ozkan, C.O., Kamalak, A. Potential nutritive value of some mediterranean shrub and tree leaves as emergency food for sheep in winter. livestock research for rural development, 2006, vol. 18, no. 6, p. 81. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

butanol-HCL method
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.3
Internal remarks:

Tannins (condensed)

Composition #2: Fleisher, A., Fleisher, Z. The volatiles of the leaves and wood of Lebanon Cedar (Cedrus libani A. Rich) aromatic plants of the Holy Land and the Sinai. Part XIV . journal of essential oil research, 2000, vol. 12, no. 6, p. 763–765. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methylene chloride and methyl alcohol
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.7-6.3
Internal remarks:

myrcene

Composition #3: Willfor, S., Hafizoglu, H., Tumen, I., Yazici, H., Arfan, M., Ali, M., Holmbom, B. Extractives of Turkish and Pakistani tree species. HOLZ ALS ROH-UND WERKSTOFF, 2007, vol. 65, no. 3, p. 215–221. DOI: 10.1007/s00107-006-0160-6. [DOI link]

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone: water (95 : 5 v/v)
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.8-11
Internal remarks:

Lignans

Endpoint study #1: Loizzo, M. R., Saab, A. M., Statti, G. A., Menichini, F. Composition and alpha-amylase inhibitory effect of essential oils from Cedrus libani . fitoterapia, 2007, vol. 78, no. 4, p. 323–326. DOI: 10.1016/j.fitote.2007.03.006. [DOI link]

Study relevance:

Human health
Plant part:

Cone (as part-nature) (A166G)
Preparation/Extraction method:

Essential oil (as part-nature) (A166Q)
Additional plant/substance description:

hydrodistillation
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

> 1
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-amylase inhibition IC50
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-amylase inhibition