Draft - work in progress
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- Cedrus deodara (Roxb. ex D.Don) G.Don
Cedrus deodara (Roxb. ex D.Don) G.Don
- Family:
- Pinaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 976
- Number of processed references:
- 4
Composition #1: Yatagai, Mitsuyoshi., Sato, Toshiya. Terpenes of leaf oils from conifers. biochemical systematics and ecology, 1986, p. 469–478. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
direct steam distillation
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Substance:
myrcene (RF-00003503-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
12.5
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Internal remarks:
myrcene
Composition #2: Lee, Na-Hyun., Lee, Sang-Min., Lee, Tae-Min., Chung, Namhyun., Lee, Hoi-Seon. GC-MS Analyses of the Essential Oils Obtained from Pinaceae Leaves in Korea. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2015, vol. 18, no. 3, p. 538–542. DOI: 10.1080/0972060X.2013.764194.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
Hydrodistillation
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Substance:
Camphor (RF-00003986-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
5.2
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Internal remarks:
Camphor
Composition #3: Lee, Na-Hyun., Lee, Sang-Min., Lee, Tae-Min., Chung, Namhyun., Lee, Hoi-Seon. GC-MS Analyses of the Essential Oils Obtained from Pinaceae Leaves in Korea. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2015, vol. 18, no. 3, p. 538–542. DOI: 10.1080/0972060X.2013.764194.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
Hydrodistillation
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Substance:
myrcene (RF-00003503-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
2.1
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Internal remarks:
Myrcene
Endpoint study
#1: Parveen, Rehana., Azmi, Muhammad A., Naqvi, Syed Naeemul H., Mahmood, Syed M., Zaidi, Ijaz H. Effect of Cedrus deodara (Pinaceae) Root Oil on the Histopathology of Rat Liver and Kidney . tropical journal of pharmaceutical research, 2010, vol. 9, no. 2, p. 127–133. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Essential oil (as part-nature) (A166Q)
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Additional plant/substance description:
dry distillation method
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Number of organisms dosed:
30
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Control groups used:
yes, concurrent no treatment
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Millilitre (G156A)
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Effect concentration:
0.5
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
Marked dilation of the central vein and prominent fatty changes
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Histopathological changes in livers
Endpoint study
#2: Parveen, Rehana., Azmi, Muhammad A., Naqvi, Syed Naeemul H., Mahmood, Syed M., Zaidi, Ijaz H. Effect of Cedrus deodara (Pinaceae) Root Oil on the Histopathology of Rat Liver and Kidney . tropical journal of pharmaceutical research, 2010, vol. 9, no. 2, p. 127–133. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Essential oil (as part-nature) (A166Q)
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Additional plant/substance description:
dry distillation method
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Number of organisms dosed:
30
-
Control groups used:
yes, concurrent no treatment
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Millilitre (G156A)
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Effect concentration:
0.5
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
atrophic changes and haemolysis in the glomerular region as well as shrinkage and shedding of glomerular epithelium in the kidney tissues
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Histopathological changes in kidneys
Endpoint study
#3: Perveen, Rehana., Azmi, Mohammad Ahmed., Zaidi, Ijaz Hussain., Naqvi, Syed Naeemul Hassan., Mahmood, Syed Mohammad., Ajmal, Kiran., Usman, Mohammad. Assessment of Cedrus deodara root oil on the histopathological changes in the gastrointestinal tissues in rats . pakistan journal of pharmaceutical sciences, 2013, vol. 26, no. 3, p. 571–576. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Essential oil (as part-nature) (A166Q)
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Additional plant/substance description:
distillation
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
Number of organisms dosed:
30
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-
Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Millilitre (G156A)
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Effect concentration:
0.5
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
Erosion of epithelium, oedema in submucosal and mucosal layers and inflammation in gastrointestinal tract
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Histropathological changes in gastrointestinal tract
