EFSA Compendium of Botanicals

Draft - work in progress

Castilla elastica Cerv.

Family:: Moraceae
Approval state:: Approved
Number of articles retrieved:: 67
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Nodal bradycardia #2: Severe vomiting with excessive salivation

Genotoxicity

Composition #1: Brauchli, P., Schindler, O., Reichstein, T. CCXXII. Cardenolides from Castilla elastica. helvetica chimica acta, 1961, p. 904–919. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

cardenolides (RF-00004389-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardenolides

Composition #2: Brauchli, P., Schindler, O., Reichstein, T. CCXXII. Cardenolides from Castilla elastica. helvetica chimica acta, 1961, p. 904–919. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Latex (as part-nature) (A166S)
Substance:

cardenolides (RF-00004389-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardenolides

Endpoint study #1: Witharana, E W R A., Wijetunga, W M G A S T B., Sathanandan, P P., Wijesinghe, S K J., Wickramaratne, L G B Y. Cardiac toxicity with nodal bradycardia due to Panama rubber (Castilla elastica: Moraceae) poisoning.. The Ceylon medical journal, 2014, vol. 59, no. 3, p. 97–8. DOI: 10.4038/cmj.v59i3.6568. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Additional plant/substance description:

green juice made from crushed leaves (2 tea spoons)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

10.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

Nodal bradycardia
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

Nodal bradycardia

Endpoint study #2: Witharana, E W R A., Wijetunga, W M G A S T B., Sathanandan, P P., Wijesinghe, S K J., Wickramaratne, L G B Y. Cardiac toxicity with nodal bradycardia due to Panama rubber (Castilla elastica: Moraceae) poisoning.. The Ceylon medical journal, 2014, vol. 59, no. 3, p. 97–8. DOI: 10.4038/cmj.v59i3.6568. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Additional plant/substance description:

green juice made from crushed leaves (2 tea spoons)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

10.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

severe vomiting with excessive salivation
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

Severe vomiting with excessive salivation