EFSA Compendium of Botanicals

Draft - work in progress

Carthamus lanatus L.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 136
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

#1: Significant differences in the percentage of aberrant mitosis of the studied samples, the types of chromosome aberrations and time-dependant effects after treatment were observed. All tested samples showed lower percentage of aberrations vs. control mitomycin C and in this sense are less harmful for mammalian cells.

Composition #1: Hussain, Iqbal., Ullah, Riaz., Ullah, Rooh., Khurram, Muhammad., Ullah, Naseem., Baseer, Abdul., Khan, Farhat Ali., ur Rehman Khattak, Muneeb., Zahoor, Mohammad., Khan, Jehangir., et al. Phytochemical analysis of selected medicinal plants. African Journal of Biotechnology, 2011, p. 7487–7492. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Milligram/100 gram (G057A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.176
Internal remarks:

alkaloids

Composition #2: Hussain, Iqbal., Ullah, Riaz., Ullah, Rooh., Khurram, Muhammad., Ullah, Naseem., Baseer, Abdul., Khan, Farhat Ali., ur Rehman Khattak, Muneeb., Zahoor, Mohammad., Khan, Jehangir., et al. Phytochemical analysis of selected medicinal plants. African Journal of Biotechnology, 2011, p. 7487–7492. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Milligram/100 gram (G057A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.516
Internal remarks:

saponins

Genotox #1: Topashka-Ancheva, M., Taskova, R., Handjieva, N., Mikhova, B., Duddeck, H. Clastogenic effect of Carthamus lanatus L. (Asteraceae). ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 2003, vol. 58, no. 11-12, p. 833–836. .

Study category:

Genotoxicity
Type of toxicological test:

chromosome aberration assay (CHD047TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male/Female
Control groups used:

yes
Is genotoxic:

Negative
Remarks on genotox study:

Significant differences in the percentage of aberrant mitosis of the studied samples, the types of chromosome aberrations and time-dependant effects after treatment were observed.
Internal remarks:

Significant differences in the percentage of aberrant mitosis of the studied samples, the types of chromosome aberrations and time-dependant effects after treatment were observed. All tested samples showed lower percentage of aberrations vs. control mitomycin C and in this sense are less harmful for mammalian cells.
Internal ID:

WOS:000188262800016