Draft - work in progress
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- Careya arborea Roxb.
Careya arborea Roxb.
- Family:
- Lecythidaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 115
- Number of processed references:
- 2
Composition #1: Ahmed, M., Rahman, MW., Rahman, MT., Hossain, CF. Analgesic principle from the bark of Careya arborea. pharmazie, 2002, vol. 57, no. 10, p. 698–701. [abstract]
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Plant part:
Bark (as part-nature) (A066X)
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Substance:
piperine (RF-00000365-NTR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Piperine
Endpoint study
#1: Kalita, Jogen Chandra., Haque, Ansarul., Kalita, Evarani., Sharma, Ronim., Rahman, M. Mukhlesur. Anti-fertility effects of the methanolic root extract of Careya arborea Roxb in albino mice. Bioscan, 2011, p. 701–706. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanolic extract
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
42
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
>=250
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Critical effect:
REPRODUCTIVE (TOX05A)
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Effect description:
40% inhibition of pregnancy, dose-dependent effect
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Inhibition of pregnancy, dosing prior to mating, dose-dependent effect
Endpoint study
#2: Kalita, Jogen Chandra., Haque, Ansarul., Kalita, Evarani., Sharma, Ronim., Rahman, M. Mukhlesur. Anti-fertility effects of the methanolic root extract of Careya arborea Roxb in albino mice. Bioscan, 2011, p. 701–706. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanolic extract
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
30
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
>=250
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Ovaries (TT047A)
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Effect description:
Estrous cyclicity
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
change in estrous cyclicity
Endpoint study
#3: Kalita, Jogen Chandra., Haque, Ansarul., Kalita, Evarani., Sharma, Ronim., Rahman, M. Mukhlesur. Anti-fertility effects of the methanolic root extract of Careya arborea Roxb in albino mice. Bioscan, 2011, p. 701–706. .
-
Study relevance:
Human health
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
methanolic extract
-
Type of toxicological test:
reproduction toxicity (CHD009TT)
-
Tested organism:
House mouse (as animal) (A0CNT)
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-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
42
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-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
>=250
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Critical effect:
REPRODUCTIVE (TOX05A)
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Effect description:
Litter size, dose-dependent effect
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Litter size, dosing prior to mating, dose-dependent effect
