EFSA Compendium of Botanicals

Draft - work in progress

Canavalia rosea (Sw.) DC // Canavalia maritima Thouars // Canavalia obtusifolia (Lam.) DC.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 100
Number of processed references:: 4

Compositions

#1: Canavanine-leaves #2: Canavanine-seeds #3: Medicarpin #4: Formononetin/ 7-hydroxy-4'-methoxyisofalvone #5: genistein/ 5,7,4'-trihydroxyisoflavone #6: Sativan/ 7-hydroxy-2',4'-dimethoxyisoflavan #7: Lectins #8: Canarosine

Endpoint Studies

Genotoxicity

Composition #1: D'Cunha, Melwyn., Sridhar, Kandikere Ramaiah. -canavanine and -arginine in two wild legumes of the genus Canavalia. IIOAB Journal, 2010, p. 29–33. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Raw, no heat treatment (A07HS)
Substance:

Canavanine (RF-00003991-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.74-0.88
Internal remarks:

Canavanine-leaves

Composition #2: D'Cunha, Melwyn., Sridhar, Kandikere Ramaiah. -canavanine and -arginine in two wild legumes of the genus Canavalia. IIOAB Journal, 2010, p. 29–33. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Raw, no heat treatment (A07HS)
Substance:

Canavanine (RF-00003991-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.17-1.7
Internal remarks:

Canavanine-seeds

Composition #3: Huang, Xinping., Mu, Bing., Lin, Wenhan., Qiu, Yan. Pterocarpin and isoflavan derivatives from Canavalia maritima (Aubl.) Thou. Records of Natural Products, 2012, p. 166–170. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

Medicarpin (RF-00011248-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Medicarpin

Composition #4: Huang, Xinping., Mu, Bing., Lin, Wenhan., Qiu, Yan. Pterocarpin and isoflavan derivatives from Canavalia maritima (Aubl.) Thou. Records of Natural Products, 2012, p. 166–170. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

formononetin (RF-00000291-NTR)
Additional substance description:

7-hydroxy-4'-methoxyisofalvone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Formononetin/ 7-hydroxy-4'-methoxyisofalvone

Composition #5: Huang, Xinping., Mu, Bing., Lin, Wenhan., Qiu, Yan. Pterocarpin and isoflavan derivatives from Canavalia maritima (Aubl.) Thou. Records of Natural Products, 2012, p. 166–170. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

genistein (RF-00000297-NTR)
Additional substance description:

5,7,4'-trihydroxyisoflavone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

genistein/ 5,7,4'-trihydroxyisoflavone

Composition #6: Huang, Xinping., Mu, Bing., Lin, Wenhan., Qiu, Yan. Pterocarpin and isoflavan derivatives from Canavalia maritima (Aubl.) Thou. Records of Natural Products, 2012, p. 166–170. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

Sativan (RF-00011020-PAR)
Additional substance description:

7-hydroxy-2',4'-dimethoxyisoflavan
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sativan/ 7-hydroxy-2',4'-dimethoxyisoflavan

Composition #7: Arruda, Francisco Vassiliepe Sousa., Melo, Arthur Alves., Vasconcelos, Mayron Alves., Carneiro, Romulo Farias., Barroso-Neto, Ito Liberato., Silva, Suzete Roberta., Pereira-Junior, Francisco Nascimento., Nagano, Celso Shiniti., Nascimento, Kyria Santiago., Teixeira, Edson Holanda., et al. Toxicity and binding profile of lectins from the genus Canavalia on brine shrimp. BioMed Research International, 2013, p. 154542/1–154542/8. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

0.9% NaCl (1:10w/v) at 20∘C for 4 h
Substance:

Lectins (RF-00000439-ORG)
Analytical method - additional description:

SDS-PAGE
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins

Composition #8: Pattamadilok, Duangpen., Pengsuparp, Thitima., Phummiratch, Duangkamol., Ongpipattanakul, Boonsri., Meksuriyen, Duangdeun., Kawanishi, Kazuko., Kaneda, Norito., Suttisri, Rutt. Canarosine: A new guanidine alkaloid from Canavalia rosea with inhibitory activity on dopamine D1 receptors. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, vol. 10, no. 10, p. 915–918. DOI: 10.1080/10286020802181513. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Canarosine (RF-00011292-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Canarosine