EFSA Compendium of Botanicals

Draft - work in progress

Caesalpinia bonduc (L.) Roxb.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 242
Number of processed references:: 3

Compositions

#1: Cardiac glycosides #2: Alkaloids #3: Coumarins #4: Tannins #5: Bonducellpins A to C #6: Cassane furanoditerpenes

Endpoint Studies

Genotoxicity

Composition #1: Sivasankari, K., Janaky, S., Sekar, T. Evaluation of phytochemicals in select medicinal plants of the Caesalpinia species. indian journal of science and technology, 2010, vol. 3, no. 12, p. 1118–1121. DOI: 10.17485/ijst/2010/v3i12/29866. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, methanol, water
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides

Composition #2: Sivasankari, K., Janaky, S., Sekar, T. Evaluation of phytochemicals in select medicinal plants of the Caesalpinia species. indian journal of science and technology, 2010, vol. 3, no. 12, p. 1118–1121. DOI: 10.17485/ijst/2010/v3i12/29866. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol,methanol, and water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: Sivasankari, K., Janaky, S., Sekar, T. Evaluation of phytochemicals in select medicinal plants of the Caesalpinia species. indian journal of science and technology, 2010, vol. 3, no. 12, p. 1118–1121. DOI: 10.17485/ijst/2010/v3i12/29866. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol,methanol and water
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #4: Sivasankari, K., Janaky, S., Sekar, T. Evaluation of phytochemicals in select medicinal plants of the Caesalpinia species. indian journal of science and technology, 2010, vol. 3, no. 12, p. 1118–1121. DOI: 10.17485/ijst/2010/v3i12/29866. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol,methanol and water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #5: Peter, SR., Tinto, WF., McLean, S., Reynolds, WF., Yu, M. Bonducellpins A-D, new cassane furanoditerpenes of Caesalpinia bonduc. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 12, p. 1219–1221. DOI: 10.1021/np970308c. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

Bonducellpin C (RF-00011206-PAR)
Additional substance description:

Bonducellpins A-C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bonducellpins A to C

Composition #6: Peter, SR., Tinto, WF., McLean, S., Reynolds, WF., Yu, M. Bonducellpins A-D, new cassane furanoditerpenes of Caesalpinia bonduc. JOURNAL OF NATURAL PRODUCTS, 1997, vol. 60, no. 12, p. 1219–1221. DOI: 10.1021/np970308c. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Cassane furanoditerpenes
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cassane furanoditerpenes

Endpoint study #1: Sukhdev, K.A., Dhondiram, M.Y., Khalure Pallavi, R., Balasaheb, C.N. Antifertility activity of root bark of Caesalpinia bonduc Linn. Roxb.in female albino rats. pharmacologyonline, 2011, vol. 3, p. 34–41. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol 70% extract
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

10.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

50-300
Critical effect:

ENDOCRINE (TOX12A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

anti-implantation activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

anti-implantation activity