EFSA Compendium of Botanicals

Draft - work in progress

Prangos pabularia Lindl.

Family:: Apiaceae (Umbelliferae)
Approval state:: Approved
Number of articles retrieved:: 108
Number of processed references:: 3

Compositions

#1: Coumarins #2: Myrcene #3: Carvone #4: Camphor #5: 6-hydroxycoumarin #6: xanthotoxol #7: heraclenol and derivatives #8: Umbelliferone #9: oxypeucedanin hydrate #10: xanthotoxin #11: Meranzin [8-((3,3-dimethyloxiran-2-yl)methyl)-7-methoxy-2H-chromen-2-one] #12: imperatorin #13: osthol

Endpoint Studies

Genotoxicity

Composition #1: Sood, Sushma., Gupta, B. D., Banerjee, S. K., Rao, P. R. Coumarins from the umbels of Prangos pabularia Lind. journal of the indian chemical society, 1978, p. 850–851. .

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

benzene-EtAc
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

isoimperatorin, osthol, suberosin, imperatorin, bergapten, xanthotoxin, isopimpinellin, oxypeucedanin and derivatives, heraclenol
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #2: Koul, S. K., Thakur, R. S. The essential oil of Prangos pabularia Lindl.. indian perfumer, 1978, vol. 22, no. 4, p. 284–6. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Myrcene

Composition #3: Koul, S. K., Thakur, R. S. The essential oil of Prangos pabularia Lindl.. indian perfumer, 1978, vol. 22, no. 4, p. 284–6. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Carvone

Composition #4: Koul, S. K., Thakur, R. S. The essential oil of Prangos pabularia Lindl.. indian perfumer, 1978, vol. 22, no. 4, p. 284–6. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Camphor

Composition #5: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

6-hydroxycoumarin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.123
Internal remarks:

6-hydroxycoumarin

Composition #6: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

Xanthotoxol (RF-00011114-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.05
Internal remarks:

xanthotoxol

Composition #7: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

heraclenol (RF-00011111-PAR)
Additional substance description:

Heraclenol and derivatives
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.26
Internal remarks:

heraclenol and derivatives

Composition #8: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.15
Internal remarks:

Umbelliferone

Composition #9: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

oxypeucedanin hydrate (RF-00003969-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.37
Internal remarks:

oxypeucedanin hydrate

Composition #10: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

xanthotoxin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.33
Internal remarks:

xanthotoxin

Composition #11: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

Meranzin (RF-00010979-PAR)
Additional substance description:

8-((3,3-dimethyloxiran-2-yl)methyl)-7-methoxy-2H-chromen-2-one
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.623
Internal remarks:

Meranzin [8-((3,3-dimethyloxiran-2-yl)methyl)-7-methoxy-2H-chromen-2-one]

Composition #12: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.455
Internal remarks:

imperatorin

Composition #13: Farooq, Saleem., Shakeel-u-Rehman., Dangroo, Nisar Ahmad., Priya, Dev., Banday, Javid Ahmad., Sangwan, Pyare Lal., Qurishi, Mushtaq Ahmad., Koul, Surrinder., Saxena, Ajit Kumar. Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia. PLOS ONE, 2014, vol. 9, no. 10 . DOI: 10.1371/journal.pone.0108713. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol/ Dichloromethane (1/1)
Substance:

osthol (RF-00011008-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.68
Internal remarks:

osthol