EFSA Compendium of Botanicals

Draft - work in progress

Bupleurum rotundifolium L.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 58
Number of processed references:: 6

Compositions

#1: Polyacetylenes #2: Rotundifoliosides A-J in fruits #3: pentacyclic triterpene saponins in aerial parts #4: 1,8-Cineole #5: myrcene #6: 2-Pentanylfuran #7: Rotundiosides A-C #8: Rotundiosides D-G

Endpoint Studies

Genotoxicity

Composition #1: Nakano, Y., Matsunaga, H., Saita, T., Mori, M., Katano, M., Okabe, H. Antiproliferative constituents in Umbelliferae plants - II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, vol. 21, no. 3, p. 257–261. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Analytical method code:

Enzyme-linked immunosorbent assay (ELISA) (F080A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polyacetylenes

Composition #2: Fujioka, T., Yoshida, K., Fujii, H., Nagao, T., Okabe, H., Mihashi, K. Antiproliferative constituents from umbelliferae plants VI. New ursane-type saikosaponin analogs from the fruits of Bupleurum rotundifolium. CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, vol. 51, no. 4, p. 365–372. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Benzene/ Methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Rotundifoliosides A-J
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

optical rotation
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Rotundifoliosides A-J in fruits

Composition #3: Nakahara, Yuko., Okawa, Masafumi., Kinjo, Junei., Nohara, Toshihiro. Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents. CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, vol. 59, no. 11, p. 1329–1339. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

rotundiosides E, V, W; Rotundifoliosides I& J
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pentacyclic triterpene saponins in aerial parts

Composition #4: Akin, Mehtap., Saracoglu, Hatice Taner., Demirci, Betul., Baser, Kemal Husnu Can., Kucukoduk, Mustafa. Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Bupleurum rotundifolium L.. RECORDS OF NATURAL PRODUCTS, 2012, vol. 6, no. 3, p. 316–320. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-FID
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.2
Internal remarks:

1,8-Cineole

Composition #5: Akin, Mehtap., Saracoglu, Hatice Taner., Demirci, Betul., Baser, Kemal Husnu Can., Kucukoduk, Mustafa. Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Bupleurum rotundifolium L.. RECORDS OF NATURAL PRODUCTS, 2012, vol. 6, no. 3, p. 316–320. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-FID
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

myrcene

Composition #6: Akin, Mehtap., Saracoglu, Hatice Taner., Demirci, Betul., Baser, Kemal Husnu Can., Kucukoduk, Mustafa. Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Bupleurum rotundifolium L.. RECORDS OF NATURAL PRODUCTS, 2012, vol. 6, no. 3, p. 316–320. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

2-Pentylfuran (RF-00008482-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-FID
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.5
Internal remarks:

2-Pentanylfuran

Composition #7: AKAI, E., TAKEDA, T., KOBAYASHI, Y., OGIHARA, Y. SULFATED TRITERPENOID SAPONINS FROM THE LEAVES OF BUPLEURUM-ROTUNDIFOLIUM-L. CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, vol. 33, no. 9, p. 3715–3723. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Rotundiosides A-C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Rotundiosides A-C

Composition #8: AKAI, E., TAKEDA, T., KOBAYASHI, Y., CHEN, Y., OGIHARA, Y. MINOR TRITERPENOID SAPONINS FROM THE LEAVES OF BUPLEURUM-ROTUNDIFOLIUM L. CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, vol. 33, no. 11, p. 4685–4690. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Rotundiosides D-G
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Rotundiosides D-G