EFSA Compendium of Botanicals

Draft - work in progress

Bryonia dioica Jacq. // Bryonia cretica L. subsp. dioica (Jacq.) Tutin

Family:: Cucurbitaceae
Approval state:: Approved
Number of articles retrieved:: 454
Number of processed references:: 3

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Yamani, Amal., Bunel, Valerian., Antoine, Marie-Helene., Husson, Cecile., Stevigny, Caroline., Duez, Pierre., Elachouri, Mostafa., Nortier, Joelle. Substitution between Aristolochia and Bryonia genus in North-Eastern Morocco: Toxicological implications. JOURNAL OF ETHNOPHARMACOLOGY, 2015, vol. 166, p. 250–260. DOI: 10.1016/j.jep.2015.03.036. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

cucurbitacins (RF-00004352-PAR)
Additional substance description:

Cucurbitacin E and I
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cucurbitacins

Composition #2: Battelli, MG., Barbieri, L., Bolognesi, A., Buonamici, L., Valbonesi, P., Polito, L., VanDamme, EJM., Peumans, WJ., Stirpe, F. Ribosome-inactivating lectins with polynucleotide: Adenosine glycosidase activity. FEBS LETTERS, 1997, vol. 408, no. 3, p. 355–359. DOI: 10.1016/S0014-5793(97)00463-8. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

not reported
Substance:

Lectins (RF-00000439-ORG)
Additional substance description:

/V-acetylgalactosamine-specific lectins
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins

Endpoint study #1: Veit, M., Martin, E. Major poisonous plants: Components and their pharmacology. Pharmazeutische Zeitung, 1998, vol. 143, no. 26, p. 11–15. .

Study relevance:

Human health
Plant part:

Fruit unspecified (as part-nature) (A067D)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Piece (G133A)
Effect concentration:

6-8
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

vomit and bloody diarrhea
Effect or parameter linked to the endpoint:

food consumption (CHD007BE)
Internal remarks:

vomit and bloody diarrhea