Draft - work in progress
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- Bryonia cretica L.
Bryonia cretica L.
- Family:
- Cucurbitaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 22
- Number of processed references:
- 4
Composition #1: Matsuda, Hisashi., Nakashima, Souichi., Abdel-Halim, Osama Bashir., Morikawa, Toshio., Yoshikawa, Masayuki. Cucurbitane-Type Triterpenes with Anti-proliferative Effects on U937 Cells from an Egyptian Natural Medicine, Bryonia cretica: Structures of New Triterpene Glycosides, Bryoniaosides A and B. CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, vol. 58, no. 5, p. 747–751. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
90% ethanol
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Substance:
Saponins (RF-00004333-PAR)
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Additional substance description:
Bryoniaoside A and B
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
optical rotation, IR, NMR, FAB-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
bryoniaoside A and B
Composition #2: Matsuda, Hisashi., Nakashima, Souichi., Abdel-Halim, Osama Bashir., Morikawa, Toshio., Yoshikawa, Masayuki. Cucurbitane-Type Triterpenes with Anti-proliferative Effects on U937 Cells from an Egyptian Natural Medicine, Bryonia cretica: Structures of New Triterpene Glycosides, Bryoniaosides A and B. CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, vol. 58, no. 5, p. 747–751. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
90% ethanol
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Substance:
cucurbitacins (RF-00004352-PAR)
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Additional substance description:
Cucurbitacins and derivatives
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
optical rotation, IR, NMR, FAB-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Cucurbitacins and derivatives
Composition #3: Sallam, Amal A., Hitotsuyanagi, Yukio., Mansour, El-Sayed S., Ahmed, Atallah F., Gedara, Sahar., Fukaya, Haruhiko., Takeya, Koichi. Cucurbitacins from Bryonia cretica. PHYTOCHEMISTRY LETTERS, 2010, vol. 3, no. 3, p. 117–121. DOI: 10.1016/j.phytol.2010.02.009.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
cucurbitacins (RF-00004352-PAR)
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Additional substance description:
Cucurbitacin G, H and J; isocucurbitacin G and H
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
melting point, IR, NMR, MS, single-crystal X-ray
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Cucurbitacins
Endpoint study
#1: Veit, M., Martin, E. Major poisonous plants: Components and their pharmacology. Pharmazeutische Zeitung, 1998, vol. 143, no. 26, p. 11–15. .
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Study relevance:
Human health
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Additional plant/substance description:
Berries
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Piece (G133A)
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Effect concentration:
6-8
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
persistent vomiting and bloody diarrhea
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Effect or parameter linked to the endpoint:
food consumption (CHD007BE)
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Internal remarks:
Persistent vomiting and bloody diarrhea
Endpoint study
#2: Al-Qura'n, S. Ethnobotanical survey of folk toxic plants in southern part of Jordan. Toxicon, 2005, vol. 46, no. 2, p. 119–129. DOI: 10.1016/j.toxicon.2005.04.010.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
intestinal inflammation
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
intestinal inflammation
