Draft - work in progress
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- Brunfelsia grandiflora D.Don. // Brunfelsia grandiflora subsp. grandiflora
Brunfelsia grandiflora D.Don. // Brunfelsia grandiflora subsp. grandiflora
- Family:
- Solanaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 22
- Number of processed references:
- 7
Composition #1: de Campos, Sonia Machado. Scopoletin in Brunfelsia seeds. Anais. Acad. Brasil Cienc., 1964, p. 511–513. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Water + HCl (pH 3-3.5)
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Substance:
scopoletin (RF-00004048-PAR)
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Analytical method - additional description:
Thin Layer Chromatography (TLC)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Scopoletin
Composition #2: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
Ethyl salicylate (RF-00008460-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.09
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Internal remarks:
Ethyl salicylate
Composition #3: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
Hex-3-enyl salicylate (RF-00002319-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.26
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Internal remarks:
3-Hexenyl salicylate
Composition #4: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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-
Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
2-Ethylfuran (RF-00008256-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.05
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Internal remarks:
2-Ethylfuran
Composition #5: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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-
Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
p-Tolualdehyde (RF-00008429-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.05
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Internal remarks:
Tolualdehyde
Composition #6: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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-
Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
Benzaldehyde (RF-00008323-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.05
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Internal remarks:
Benzaldehyde
Composition #7: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
steam distillation
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Substance:
methyl salicylate (RF-00003930-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
61.49
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Internal remarks:
Methyl salicylate
Composition #8: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
Pentyl salicylate (RF-00001820-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.07
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Internal remarks:
Pentyl salicylate
Composition #9: Castioni, P., Kapetanidis, I. Volatile constituents from Brunfelsia grandiflora ssp. grandiflora: Qualitative analysis by GC-MS. Scientia Pharmaceutica, 1996, vol. 64, no. 1, p. 83–91. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
steam distillation
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Substance:
Isobutyl salicylate (RF-00007775-PAR)
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Analytical method code:
GC-FID (F040A)
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Analytical method - additional description:
GC-MS, GC-FID
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.07
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Internal remarks:
Isobutyl salicylate
Composition #10: Jauregui, X., Clavo, Z.M., Jovel, E.M., Pardo-De-Santayana, M. "Plantas con madre": Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon. Journal of Ethnopharmacology, 2011, vol. 134, no. 3, p. 739–752. DOI: 10.1016/j.jep.2011.01.042.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
decoction
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Substance:
scopoletin (RF-00004048-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Scopoletin- Roots
Composition #11: Jauregui, X., Clavo, Z.M., Jovel, E.M., Pardo-De-Santayana, M. "Plantas con madre": Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon. Journal of Ethnopharmacology, 2011, vol. 134, no. 3, p. 739–752. DOI: 10.1016/j.jep.2011.01.042.
[
DOI link]
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Plant part:
Bark (as part-nature) (A066X)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
decoction
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Substance:
scopoletin (RF-00004048-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Scopoletin- Bark
Composition #12: Jauregui, X., Clavo, Z.M., Jovel, E.M., Pardo-De-Santayana, M. "Plantas con madre": Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon. Journal of Ethnopharmacology, 2011, vol. 134, no. 3, p. 739–752. DOI: 10.1016/j.jep.2011.01.042.
[
DOI link]
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Plant part:
Trunk (as part-nature) (A166N)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
decoction
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Substance:
scopoletin (RF-00004048-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Scopoletin- Trunk
Composition #13: Fuchino, Hiroyuki., Sekita, Setsuko., Mori, Kanami., Kawahara, Nobuo., Satake, Motoyoshi., Kiuchi, Fumiyuki. A new leishmanicidal saponin from Brunfelsia grandiflora. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, vol. 56, no. 1, p. 93–96. DOI: 10.1248/cpb.56.93.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
cirensenoside P (RF-00010964-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
melting point, optical rotations, IR, NMR, GC-MS, LC-MS, FAB-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
cirensenoside P
Composition #14: Fuchino, Hiroyuki., Sekita, Setsuko., Mori, Kanami., Kawahara, Nobuo., Satake, Motoyoshi., Kiuchi, Fumiyuki. A new leishmanicidal saponin from Brunfelsia grandiflora. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, vol. 56, no. 1, p. 93–96. DOI: 10.1248/cpb.56.93.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
scopoletin (RF-00004048-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
melting point, optical rotations, IR, NMR, GC-MS, LC-MS, FAB-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
scopoletin
Composition #15: Sanz-Biset, Jaume., Canigueral, Salvador. Plant use in the medicinal practices known as "strict diets" in Chazuta valley (Peruvian Amazon). JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 1, p. 271–288. DOI: 10.1016/j.jep.2011.05.021.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Fresh water
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Substance:
Pyrrolidone (RF-00011051-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
2-Pyrrolidinone
Composition #16: Sanz-Biset, Jaume., Canigueral, Salvador. Plant use in the medicinal practices known as "strict diets" in Chazuta valley (Peruvian Amazon). JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 1, p. 271–288. DOI: 10.1016/j.jep.2011.05.021.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Fresh water
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Substance:
Brunfelsamidine (RF-00011052-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
brunfelsamidine
Composition #17: Sanz-Biset, Jaume., Canigueral, Salvador. Plant use in the medicinal practices known as "strict diets" in Chazuta valley (Peruvian Amazon). JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 1, p. 271–288. DOI: 10.1016/j.jep.2011.05.021.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Fresh water
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Substance:
scopoletin (RF-00004048-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Scopoletin
Composition #18: Sanz-Biset, Jaume., Canigueral, Salvador. Plant use in the medicinal practices known as "strict diets" in Chazuta valley (Peruvian Amazon). JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 1, p. 271–288. DOI: 10.1016/j.jep.2011.05.021.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Fresh water
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Substance:
methyl salicylate (RF-00003930-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
methyl salicylate
Composition #19: LLOYD, HA., FALES, HM., GOLDMAN, ME., JERINA, DM., PLOWMAN, T., SCHULTES, RE. BRUNFELSAMIDINE - A NOVEL CONVULSANT FROM THE MEDICINAL PLANT BRUNFELSIA-GRANDIFLORA. TETRAHEDRON LETTERS, 1985, vol. 26, no. 22, p. 2623–2624. DOI: 10.1016/S0040-4039(00)98119-X.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Brunfelsamidine (RF-00011052-PAR)
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Additional substance description:
pyrrol-3-carboxamidine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
NMR, MS,UV
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
brunfelsamidine
Composition #20: LLOYD, HA., FALES, HM., GOLDMAN, ME., JERINA, DM., PLOWMAN, T., SCHULTES, RE. BRUNFELSAMIDINE - A NOVEL CONVULSANT FROM THE MEDICINAL PLANT BRUNFELSIA-GRANDIFLORA. TETRAHEDRON LETTERS, 1985, vol. 26, no. 22, p. 2623–2624. DOI: 10.1016/S0040-4039(00)98119-X.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
scopoletin (RF-00004048-PAR)
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Analytical method code:
Mass Spectroscopy and hyphenated methods without chromatography (F063A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
scopoletin
Endpoint study
#1: BENNETT, BC. HALLUCINOGENIC PLANTS OF THE SHUAR AND RELATED INDIGENOUS GROUPS IN AMAZONIAN ECUADOR AND PERU. BRITTONIA, 1992, vol. 44, no. 4, p. 483–493. DOI: 10.2307/2807199.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water infusion
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: DRINKING WATER (OECD2229PL)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
hallucination
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
hallucinogen