EFSA Compendium of Botanicals

Draft - work in progress

Brugmansia suaveolens (Humb. & Bonpl. ex Willd.) Bercht. & J.Presl // Datura suaveolens Humb. & Bonpl. ex Willd.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 86
Number of processed references:: 8

Compositions

#1: Hyoscine in leaves #2: tropane alkaloids in stems #3: tropane alkaloids in fully grown leaves #4: total alkaloids #5: Tropane alkaloids #6: Scopolamine in nectar #7: Scopolamine (alkaloid) in leaves #8: Scopolamine in stems (alkaloid) #9: Scopolamine in roots (alkaloid) #10: Scopolamine in flowers (alkaloid) #11: Scopolamine in fruits (alkaloid) #12: 1,8-cineole

Endpoint Studies

#1: neurotoxicity - anticholinergic effect #2: neurotoxicity

Genotoxicity

Composition #1: Grupta, B. K., Vishwa, Paul., Handa, K. L., Kapoor, L. D. Hyoscine is the chief constituent of Datura suaveolens leaves. proceedings of the national academy of sciences, india, section a: physical sciences, 1965, p. 261–262. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Scopolamine (RF-00000248-TOX)
Additional substance description:

Hyoscine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

80
Internal remarks:

Hyoscine in leaves

Composition #2: Balbaa, S. I., Saber, A. Hifny., Karawya, M. S., El-Hossary, G. A. Alkaloid content of Datura suaveolens grown in Egypt. journal of pharmaceutical sciences of the united arab republic, 1969, p. 125–134. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Tropane alkaloids (RF-00000245-TOX)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.37
Internal remarks:

tropane alkaloids in stems

Composition #3: Balbaa, S. I., Saber, A. Hifny., Karawya, M. S., El-Hossary, G. A. Alkaloid content of Datura suaveolens grown in Egypt. journal of pharmaceutical sciences of the united arab republic, 1969, p. 125–134. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Tropane alkaloids (RF-00000245-TOX)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.318
Internal remarks:

tropane alkaloids in fully grown leaves

Composition #4: Evans, W. C., Lampard, J. F. Alkaloids of the genus Datura section Brugmansia. VIII. Alkaloids of Datura suaveolens. Phytochemistry (Elsevier), 1972, p. 3293–3298. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.64
Internal remarks:

total alkaloids

Composition #5: Evans, W. C., Lampard, J. F. Alkaloids of the genus Datura section Brugmansia. VIII. Alkaloids of Datura suaveolens. Phytochemistry (Elsevier), 1972, p. 3293–3298. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum, ether, chloroform
Substance:

Tropane alkaloids (RF-00000245-TOX)
Additional substance description:

hyoscine, apohyoscine, norhyoscine, atropine, noratropine, tigloyl esters
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

TLC, UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tropane alkaloids

Composition #6: Kerchner Andras., Darok Judit., Bacskay Ivett., Felinger Attila., Jakab Gabor., Farkas Agnes. Protein and alkaloid patterns of the floral nectar in some solanaceous species. acta biologica hungarica, 2015, p. 304–315. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopolamine in nectar

Composition #7: Alves, Marcos Nopper., Sartoratto, Adilson., Trigo, Jose Roberto. Scopolamine in Brugmansia suaveolens (Solanaceae): Defense, allocation, costs, and induced response . journal of chemical ecology, 2007, vol. 33, no. 2, p. 297–309. DOI: 10.1007/s10886-006-9214-9. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol,
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method - additional description:

GC-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.8-1.1
Internal remarks:

Scopolamine (alkaloid) in leaves

Composition #8: Alves, Marcos Nopper., Sartoratto, Adilson., Trigo, Jose Roberto. Scopolamine in Brugmansia suaveolens (Solanaceae): Defense, allocation, costs, and induced response . journal of chemical ecology, 2007, vol. 33, no. 2, p. 297–309. DOI: 10.1007/s10886-006-9214-9. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method - additional description:

GC-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.8-1.0
Internal remarks:

Scopolamine in stems (alkaloid)

Composition #9: Alves, Marcos Nopper., Sartoratto, Adilson., Trigo, Jose Roberto. Scopolamine in Brugmansia suaveolens (Solanaceae): Defense, allocation, costs, and induced response . journal of chemical ecology, 2007, vol. 33, no. 2, p. 297–309. DOI: 10.1007/s10886-006-9214-9. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method - additional description:

GC-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-0.3
Internal remarks:

Scopolamine in roots (alkaloid)

Composition #10: Alves, Marcos Nopper., Sartoratto, Adilson., Trigo, Jose Roberto. Scopolamine in Brugmansia suaveolens (Solanaceae): Defense, allocation, costs, and induced response . journal of chemical ecology, 2007, vol. 33, no. 2, p. 297–309. DOI: 10.1007/s10886-006-9214-9. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method - additional description:

GC-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3-1.5
Internal remarks:

Scopolamine in flowers (alkaloid)

Composition #11: Alves, Marcos Nopper., Sartoratto, Adilson., Trigo, Jose Roberto. Scopolamine in Brugmansia suaveolens (Solanaceae): Defense, allocation, costs, and induced response . journal of chemical ecology, 2007, vol. 33, no. 2, p. 297–309. DOI: 10.1007/s10886-006-9214-9. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Scopolamine (RF-00000248-TOX)
Analytical method - additional description:

GC-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.8-2.0
Internal remarks:

Scopolamine in fruits (alkaloid)

Composition #12: Anthony, Samuel J., Zuchowski, Willow., Setzer, William N. Composition of the Floral Essential Oil of Brugmansia suaveolens. records of natural products, 2009, vol. 3, no. 2, p. 76–81. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.0-72.1
Internal remarks:

1,8-cineole

Endpoint study #1: Chang, S.-S., Wu, M.-L., Deng, J.-F., Lee, C.-C., Chin, T.-F., Liao, S.-J. Poisoning by Datura leaves used as edible wild vegetables. Veterinary and Human Toxicology, 1999, vol. 41, no. 4, p. 242–245. .

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Thermal treatment (heating for preservation) (A07HR)
Additional plant/substance description:

soup
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

30.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

14
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

dizziness, flushed skin, agitation, nausea, blured vision, hypertension, delirium, vomiting, hyperthermia, fever and dry mouth; anticholinergic effect
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

neurotoxicity - anticholinergic effect

Endpoint study #2: Sevketoglu, Esra., Tatli, Burak., Tugcu, Betul., Demirelli, Yasar., Hatipoglu, Sami. An Unusual Cause of Fulminant Guillain-Barre Syndrome: Angel's Trumpet. PEDIATRIC NEUROLOGY, 2010, vol. 43, no. 5, p. 368–370. DOI: 10.1016/j.pediatrneurol.2010.05.019. [DOI link]

Study relevance:

Human health
Plant part:

Flower (as part-nature) (A067B)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

The patient was discovered with Guillain-Barre´ syndrome and unilateral tonic pupil. Patient had speaking and swallowing, dry mouth with red, inflamed oral mucosa with coated tongue.
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

neurotoxicity