EFSA Compendium of Botanicals

Draft - work in progress

Broussonetia papyrifera (L.) L'Hér. ex Vent.

Family:: Moraceae
Approval state:: Approved
Number of articles retrieved:: 688
Number of processed references:: 7

Compositions

#1: Epoxides #2: Isoquinoline alkaloids #3: alkaloids #4: Tannins #5: Saponins #6: Cardiac glycosides #7: Phlobotannins #8: Moracin N #9: Scopoletin #10: Lignans #11: Dihydrosanguinarine (alkaloid) #12: N-norchelerythrine (alkaloid)

Endpoint Studies

#1: alpha-glucosidase inhibitory activity

Genotoxicity

Composition #1: Xu Xiao-Hua., Qian Shi-Hui., Bian Mei-Guang., Xie Ning., Yang Nian-Yun., Duan Jin-Ao. Chemical constituents from the leaves of Broussonetia papyrifera. Chinese Journal of Natural Medicines, 2007, vol. 5, no. 3, p. 190–192. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone (50%)
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Epoxides

Composition #2: Pang, Su-Qiu., Wang, Guo-Quan., Huang, Bao-Kang., Zhang, Qiao-Yan., Qin, Lu-Ping. Isoquinoline alkaloids from Broussonetia papyrifera fruits. CHEMISTRY OF NATURAL COMPOUNDS, 2007, vol. 43, no. 1, p. 100–102. DOI: 10.1007/s10600-007-0042-0. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 80%
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

broussonpapyrine, nitidine, oxyavicine and liriodenine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #3: Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings . journal of medicinal plants research, 2011, vol. 5, no. 25, p. 6017–6023. DOI: 10.5897/JMPR11.869. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.74
Internal remarks:

alkaloids

Composition #4: Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings . journal of medicinal plants research, 2011, vol. 5, no. 25, p. 6017–6023. DOI: 10.5897/JMPR11.869. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.56
Internal remarks:

Tannins

Composition #5: Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings . journal of medicinal plants research, 2011, vol. 5, no. 25, p. 6017–6023. DOI: 10.5897/JMPR11.869. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.53
Internal remarks:

Saponins

Composition #6: Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings . journal of medicinal plants research, 2011, vol. 5, no. 25, p. 6017–6023. DOI: 10.5897/JMPR11.869. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides

Composition #7: Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings . journal of medicinal plants research, 2011, vol. 5, no. 25, p. 6017–6023. DOI: 10.5897/JMPR11.869. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

phlobotannins (RF-00011481-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phlobotannins

Composition #8: Luo, Liping., Shen, Liming., Sun, Fang., Dai, Yujie., Zheng, Heng., Ma, Zhongjun., Xu, Ying., Guo, Zengjun. Screening for aromatase ligands in the extract of Broussonetia papyrifera using high performance liquid chromatography and ESI-mass spectrometry. ANALYTICAL METHODS, 2012, vol. 4, no. 1, p. 230–235. DOI: 10.1039/c1ay05659j. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

Moracin N (RF-00011207-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

ESI MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Moracin N

Composition #9: Luo, Liping., Shen, Liming., Sun, Fang., Dai, Yujie., Zheng, Heng., Ma, Zhongjun., Xu, Ying., Guo, Zengjun. Screening for aromatase ligands in the extract of Broussonetia papyrifera using high performance liquid chromatography and ESI-mass spectrometry. ANALYTICAL METHODS, 2012, vol. 4, no. 1, p. 230–235. DOI: 10.1039/c1ay05659j. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

ESI/MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin

Composition #10: Ran Xiao-Ku., Wang Xiao-Tong., Liu Pei-Pei., Chi Yu-Xin., Wang Bo-Jia., Dou De-Qiang., Kang Ting-Guo., Xiong Wei. Cytotoxic constituents from the leaves of Broussonetia papyrifera. chinese journal of natural medicines, 2013, vol. 11, no. 3, p. 269–273. DOI: 10.3724/SP.J.1009.2013.00269. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

lignans (RF-00004361-PAR)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #11: Pang, Su-Qiu., Wang, Guo-Quan., Lin, Jun-Sheng., Diao, Yong., Xu, Rui-An. Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits. PHARMACEUTICAL BIOLOGY, 2014, vol. 52, no. 10, p. 1315–1319. DOI: 10.3109/13880209.2014.891139. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether, ethyl acetate, ethanol, chloroform, ammonia, and sulfuric acid
Substance:

dihydrosanguinarine (RF-00003780-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dihydrosanguinarine (alkaloid)

Composition #12: Pang, Su-Qiu., Wang, Guo-Quan., Lin, Jun-Sheng., Diao, Yong., Xu, Rui-An. Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits. PHARMACEUTICAL BIOLOGY, 2014, vol. 52, no. 10, p. 1315–1319. DOI: 10.3109/13880209.2014.891139. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether, ethyl acetate, ethanol, chloroform, ammonia, and sulfuric acid
Substance:

Norchelerythrine (RF-00011055-PAR)
Additional substance description:
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-norchelerythrine (alkaloid)

Endpoint study #1: Ryu, Hyung Won., Lee, Byong Won., Curtis-Long, Marcus J., Jung, Sunin., Ryu, Young Bae., Lee, Woo Song., Park, Ki Hun. Polyphenols from Broussonetia papyrifera Displaying Potent alpha-Glucosidase Inhibition. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, vol. 58, no. 1, p. 202–208. DOI: 10.1021/jf903068k. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Brossoflurenone A, B; Broussochalcone A, B; Kazinol A, B, E; 3,4-Dihydroxyisolonchocarpin
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.0021
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibitory activity
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibitory activity