EFSA Compendium of Botanicals

Draft - work in progress

Berberis aristata DC.

Family:: Berberidaceae
Approval state:: Approved
Number of articles retrieved:: 384
Number of processed references:: 5

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Blasko, Gabor., Murugesan, Natesan., Freyer, Alan J., Shamma, Maurice., Ansari, Akber Ali., Atta-ur-Rahman. Karachine: an unusual protoberberine alkaloid. Journal of the American Chemical Society, 1982, p. 2039–2041. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Karachine (RF-00011158-PAR)
Additional substance description:
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.7
Internal remarks:

Karachine (isoquinoline alkaloid)

Composition #2: Atta-ur-Rahman., Ansari, Akbar Ali. Alkaloids of Berberis aristata - isolation of aromoline and oxyberberine. journal of the chemical society of pakistan, 1983, p. 283–284. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

root bark and hot ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

aromoline, berbamine, oxyacanthine, oxyberberine
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #3: Sreevidya, N., Mehrotra, S. Spectrophotometric method for estimation of alkaloids precipitable with Dragendorff's reagent in plant materials . journal of aoac international, 2003, vol. 86, no. 6, p. 1124–1127. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform–ether–alcohol (90%; 23 + 8 + 2.5)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

total alkaloids
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.567- 0.581
Internal remarks:

total alkaloids

Composition #4: Bajpai, Vikas., Singh, Awantika., Arya, Kamal Ram., Srivastava, Mukesh., Kumar, Brijesh. Rapid screening for the adulterants of Berberis aristata using direct analysis in real-time mass spectrometry and principal component analysis for discrimination. EXPOSURE & RISK ASSESSMENT, 2015, vol. 32, no. 6, p. 799–807. DOI: 10.1080/19440049.2015.1022885. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

berbamine, berberrubine, ketoberberine, pakistanamine, protoberberine
Analytical method - additional description:

DART MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #5: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

isocorydine (RF-00003443-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

Isocorydine (isoquinoline alkaloid)- flower

Composition #6: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

glaucine (RF-00003838-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4
Internal remarks:

Glaucine (isoquinoline alkaloid)-flowers

Composition #7: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.07
Internal remarks:

Jatrorrhizine (isquinoline alkaloid)-flowers

Composition #8: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Canadine (RF-00011169-PAR)
Additional substance description:
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5
Internal remarks:

Tetrahydroberberine (isoquinoliine alkaloid) - stem

Composition #9: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5
Internal remarks:

Magnoflorine (isoquinoline alkloid) - flower

Composition #10: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

palmatine (RF-00003971-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

78.9
Internal remarks:

Palmatine (isoquinoline alkaloid) - root

Composition #11: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

berberine (RF-00003706-PAR)
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.7
Internal remarks:

Berberine (isoquinoline alkaloid) -flower

Composition #12: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Additional substance description:
Analytical method - additional description:

UHPLC–ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.28
Internal remarks:

Tetrahydropalmatine (isoquinoline alkaloid)

Composition #13: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4
Internal remarks:

magnoflorine (isoquinoline alkaloid) -leaves

Composition #14: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.8
Internal remarks:

magnoflorine (isoquinoline alkaloid)-roots

Composition #15: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

26.3
Internal remarks:

magnoflorine (isoquinoline alkaloid)- stem

Composition #16: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

isocorydine (RF-00003443-PAR)
Analytical method - additional description:

UHPLCX-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.34
Internal remarks:

isocorydine (isoquinoline alkaloid)-stem

Composition #17: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2
Internal remarks:

Jatrorrhizine (isoquinoline alkaloid)-leaf

Composition #18: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.7
Internal remarks:

jatrorrhizine (isoquinolin alkaloid>) -root

Composition #19: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.7
Internal remarks:

jatrorrhizine (isoquinoline alkaloid) -stem

Composition #20: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

palmatine (RF-00003971-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.1
Internal remarks:

palmatine (ioquinoline alkaloid)-stem

Composition #21: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EToH
Substance:

berberine (RF-00003706-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

Berberine (isoquinoline alkaloid)- leaves

Composition #22: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

berberine (RF-00003706-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

121.8
Internal remarks:

berberine (isoquinoline alkaloid)-root

Composition #23: Singh, Awantika., Bajpai, Vikas., Kumar, Sunil., Arya, Kamal Ram., Sharma, Kulwant Rai., Kumar, Brijesh. Quantitative determination of isoquinoline alkaloids and chlorogenic acid in Berberis species using ultra high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 12, p. 2007–2013. DOI: 10.1002/jssc.201500063. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

berberine (RF-00003706-PAR)
Analytical method - additional description:

UHPLC-ESI-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

102.3
Internal remarks:

Berberine (isoquinoline alkaloid)- stem