EFSA Compendium of Botanicals

Draft - work in progress

Barbarea vulgaris W. T. Aiton

Family:: Brassicaceae
Approval state:: Approved
Number of articles retrieved:: 432
Number of processed references:: 6

Compositions

#1: Glucosinolates #2: Calystegines ( tropane alkaloids) #3: gluconasturtiin (glucosinolate) #4: glucobarbarin (glucosinolate) #5: glucosibarin (glucosinolate) #6: glucobrassicin (glucosinolates) #7: hederagenin cellobioside (triterpene saponin) #8: Pentacyclic tritepene saponins (chocalic acid cellobioside, oleanoic acid cellobioside) #9: Glucobarbarin (glucosinolate)

Endpoint Studies

#1: decreased growth

Genotoxicity

Composition #1: Bennett, Richard N., Mellon, Fred A., Kroon, Paul A. Screening crucifer seeds as sources of specific intact glucosinolates using ion-pair high-performance liquid chromatography negative ion electrospray mass spectrometry.. journal of agricultural and food chemistry, 2004, vol. 52, no. 3, p. 428–438. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 70% (v/v)
Substance:

Glucosinolates (RF-00000330-TOX)
Additional substance description:

glucosinolates derived from L-phenylanine and L-tyrosine (PE series 55, 56 and 57)
Result unit:

Gram/kilogram (G015A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.044-33.0
Internal remarks:

Glucosinolates

Composition #2: Brock, Andrea., Herzfeld, Tobias., Paschke, Reinhard., Koch, Marcus., Draeger, Birgit. Brassicaceae contain nortropane alkaloids.. Phytochemistry (Elsevier), 2006, vol. 67, no. 18, p. 2050–2057. DOI: 10.1016/j.phytochem.2006.06.024. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

Calystegines (RF-00010841-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calystegines ( tropane alkaloids)

Composition #3: Andersson, AAM., Merker, A., Nilsson, P., Sorensen, H., Aman, P. Chemical composition of the potential new oilseed crops Barbarea vulgaris, Barbarea verna and Lepidium campestre. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1999, vol. 79, no. 2, p. 179–186. DOI: 10.1002/(SICI)1097-0010(199902)79:2<179::AID-JSFA163>3.0.CO;2-N. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

gluconasturtiin (RF-00003843-PAR)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.24-5.30
Internal remarks:

gluconasturtiin (glucosinolate)

Composition #4: Andersson, AAM., Merker, A., Nilsson, P., Sorensen, H., Aman, P. Chemical composition of the potential new oilseed crops Barbarea vulgaris, Barbarea verna and Lepidium campestre. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1999, vol. 79, no. 2, p. 179–186. DOI: 10.1002/(SICI)1097-0010(199902)79:2<179::AID-JSFA163>3.0.CO;2-N. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

glucobarbarin (RF-00011340-PAR)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

41.25-59.70
Internal remarks:

glucobarbarin (glucosinolate)

Composition #5: Andersson, AAM., Merker, A., Nilsson, P., Sorensen, H., Aman, P. Chemical composition of the potential new oilseed crops Barbarea vulgaris, Barbarea verna and Lepidium campestre. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1999, vol. 79, no. 2, p. 179–186. DOI: 10.1002/(SICI)1097-0010(199902)79:2<179::AID-JSFA163>3.0.CO;2-N. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Sap (as part-nature) (A166V)
Substance:

glucosibarin (RF-00010875-PAR)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.57-5.44
Internal remarks:

glucosibarin (glucosinolate)

Composition #6: Andersson, AAM., Merker, A., Nilsson, P., Sorensen, H., Aman, P. Chemical composition of the potential new oilseed crops Barbarea vulgaris, Barbarea verna and Lepidium campestre. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1999, vol. 79, no. 2, p. 179–186. DOI: 10.1002/(SICI)1097-0010(199902)79:2<179::AID-JSFA163>3.0.CO;2-N. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

glucobrassicin (RF-00003840-PAR)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.58-5.56
Internal remarks:

glucobrassicin (glucosinolates)

Composition #7: Kuzina, Vera., Nielsen, Jens Kvist., Augustin, Jorg Manfred., Torp, Anna Maria., Bak, Soren., Andersen, Sven Bode. Barbarea vulgaris linkage map and quantitative trait loci for saponins, glucosinolates, hairiness and resistance to the herbivore Phyllotreta nemorum . phytochemistry, 2011, vol. 72, no. 2-3, p. 188–198. DOI: 10.1016/j.phytochem.2010.11.007. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

3-O-Cellobiosyl-hederagenin
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hederagenin cellobioside (triterpene saponin)

Composition #8: Kuzina, Vera., Nielsen, Jens Kvist., Augustin, Jorg Manfred., Torp, Anna Maria., Bak, Soren., Andersen, Sven Bode. Barbarea vulgaris linkage map and quantitative trait loci for saponins, glucosinolates, hairiness and resistance to the herbivore Phyllotreta nemorum . phytochemistry, 2011, vol. 72, no. 2-3, p. 188–198. DOI: 10.1016/j.phytochem.2010.11.007. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

chocalic acid cellobioside, oleanoic acid cellobioside
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic tritepene saponins (chocalic acid cellobioside, oleanoic acid cellobioside)

Composition #9: Bianco, Giuliana., Agerbirk, Niels., Losito, Ilario., Cataldi, Tommaso R. I. Acylated glucosinolates with diverse acyl groups investigated by high resolution mass spectrometry and infrared multiphoton dissociation. PHYTOCHEMISTRY, 2014, vol. 100, p. 92–102. DOI: 10.1016/j.phytochem.2014.01.010. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Aqueous methanol
Substance:

glucobarbarin (RF-00011340-PAR)
Analytical method code:

Electrochemical tests (F012A)
Analytical method - additional description:

IRMPD and ESI-FTICR MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glucobarbarin (glucosinolate)

Endpoint study #1: Bergeron, Jean Marie., Goulet, Marie. Study on the phytoestrogenic and phytotoxic effects of open-land plants on the laboratory mouse.. canadian journal of zoology, 1980, vol. 58, no. 9, p. 1575–81. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Crl: COBS CD BR - Rat (CHD163ST)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

6.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

50
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

DEVELOPMENTAL (TOX07A)
Effect description:

53.1% decreased growth compared to control group
Effect or parameter linked to the endpoint:

growth (CHD009BE)
Internal remarks:

decreased growth