EFSA Compendium of Botanicals

Draft - work in progress

Ballota nigra L. // Ballota foetida Lam.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 140
Number of processed references:: 6

Compositions

#1: saponins #2: 7alpha-acetoxymarrubiin (furan derivative) #3: ballonigrin (furan derivative) #4: phenylpropanoids #5: furan derivative (13-hydroxyballonigrinolide) #6: 7alpha-acetoxyroyleanone (diterpene ketone) #7: 1,8-cineole #8: balletetroside (aerial part)

Endpoint Studies

Genotoxicity

Composition #1: Balansard, J. Pharmacological study of Ballota foetida.. comptes rendus des seances de la societe de biologie et de ses filiales, 1934, vol. 115, p. 1295–7. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #2: Savona, Giuseppe., Piozzi, Franco., Hanson, James R., Siverns, Michael. Structures of three new diterpenoids from Ballota species.. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977, no. 3, p. 322–4. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

7alpha-acetoxymarrubiin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7alpha-acetoxymarrubiin (furan derivative)

Composition #3: Savona, Giuseppe., Piozzi, Franco., Hanson, James R., Siverns, Michael. Structures of three new diterpenoids from Ballota species.. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977, no. 3, p. 322–4. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

ballonigrin (RF-00011178-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ballonigrin (furan derivative)

Composition #4: Seidel, Veronique., Bailleul, Francois., Tillequin, Francois. Terpenoids and phenolics in the genus Ballota L. (Lamiaceae).. recent research developments in phytochemistry, 1999, vol. 3, p. 27–39. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

e.g. forsythioside B, arenarioside, ballotetroside, verbascoside
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4
Internal remarks:

phenylpropanoids

Composition #5: Seidel, Veronique., Bailleul, Francois., Tillequin, Francois. Terpenoids and phenolics in the genus Ballota L. (Lamiaceae).. recent research developments in phytochemistry, 1999, vol. 3, p. 27–39. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

13-hydroxyballonigrinolide
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

furan derivative (13-hydroxyballonigrinolide)

Composition #6: Toth, Eniko., Toth, Gabor., Mathe, Imre., Blunden, Gerald. Martynoside, forsythoside B, ladanein and 7a-acetoxyroyleanone from Ballota nigra L.. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2007, vol. 35, no. 12, p. 894–897. DOI: 10.1016/j.bse.2007.04.009. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH extraction,
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

7alpha-acetoxyroyleanone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7alpha-acetoxyroyleanone (diterpene ketone)

Composition #7: Jamzad, Mina., Rustaiyan, Abdolhossein., Jamzad, Ziba., Masoudi, Shiva. Essential Oil Composition of Salvia indica L., Thymus caucasicus Wind. Ex Ronniger subsp Grossheimii (Ronniger) Jalas. and Ballota nigra L. Three Labiatae Species from Iran . journal of essential oil bearing plants, 2011, vol. 14, no. 1, p. 76–83. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.6
Internal remarks:

1,8-cineole

Composition #8: Seidel, V., Bailleul, F., Libot, F., Tillequin, F. A phenylpropanoid glycoside from Ballota nigra. phytochemistry, 1997, vol. 44, no. 4, p. 691–693. DOI: 10.1016/S0031-9422(96)00578-X. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Ballotetroside (RF-00011391-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

balletetroside (aerial part)