Composition #1: JARVIS, BB., PENA, NB., NILGUNCOMEZOGLU, S., RAO, MM. NON-TRICHOTHECENES FROM BACCHARIS-MEGAPOTAMICA. PHYTOCHEMISTRY, 1986, vol. 25, no. 2, p. 533–535. DOI: 10.1016/S0031-9422(00)85519-3.
[DOI link]
Language:
English (en)
Plant part:
Unspecified (A07XD)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Hexane and methanol
Substance:
scopoletin (RF-00004048-PAR)
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:
Crystallization, IR, UV, NMR,
Result unit:
Gram/kilogram (G015A)
Result type:
Numerical Value (VAL)
Value (concentration, content):
> 0.40
Internal remarks:
scopoletin
Composition #2: JARVIS, BB., PENA, NB., NILGUNCOMEZOGLU, S., RAO, MM. NON-TRICHOTHECENES FROM BACCHARIS-MEGAPOTAMICA. PHYTOCHEMISTRY, 1986, vol. 25, no. 2, p. 533–535. DOI: 10.1016/S0031-9422(00)85519-3.
[DOI link]
Language:
English (en)
Plant part:
Unspecified (A07XD)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
Hexane and methanol
Substance:
benzoquinones (RF-00010840-PAR)
Additional substance description:
2,6-dimethoxybenzoquinone
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:
Crystallization, IR, UV, NMR,
Result unit:
Gram/kilogram (G015A)
Result type:
Numerical Value (VAL)
Value (concentration, content):
>1.5
Internal remarks:
2,6-dimethoxybenzoquinone
Endpoint study
#1: Barbosa, Jose Diomedes., Armien, Anibal Guillermo., Tokarnia, Carlos Hubinger. Experimental poisoning of goats by Baccharis megapotamica var. weirii (Compositae). Pesquisa Veterinaria Brasileira, 1994, vol. 14, no. 1, p. 5–13. .
Study relevance:
Animal (target species) health
Plant part:
Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:
Solvent extraction (A0BZR)
Type of toxicological test:
case report (CHD060TT)
Tested organism:
Goat (as animal) (A057P)
Sex:
Male/Female
Route of exposure:
ORAL: FEED (OECD2230PL)
Exposure duration:
4.13
Unit of exposure duration:
Hour (G099A)
Number of organisms dosed:
11
Control groups used:
no
Endpoint measured:
Dose level (CHD014EP)
Concentration unit:
Gram/kilogram (G015A)
Effect concentration:
2
Critical effect:
Digestive (TOX18A)
Target tissue:
digestive: Stomach (TT027A)
Effect description:
Death
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
Internal remarks:
Disturbance of the digestive tract. Main symptoms: anorexia, ruminal atonia, increase of the intestinal peristaltism, modification in the consistency of the faeces, tachycardia and dispnoea; in addition: restlessness, depression, muscular tremor, dehydration, sialorrhoea, hypothermia (terminal phase)
