Draft - work in progress
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- Atractylodes macrocephala Koidz.
Atractylodes macrocephala Koidz.
- Family:
- Compositae (Asteraceae)
- Approval state:
- Approved
- Number of articles retrieved:
- 2671
- Number of processed references:
- 2
Composition #1: Chen, Liang-Yu., Hu, Anren., Chang, Chih-Jui. The degradation mechanism of toxic atractyloside in herbal medicines by decoction.. molecules, 2013, vol. 18, p. 2018–2028. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Aqueous extraction
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Substance:
atractyloside (RF-00004170-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
9230
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Internal remarks:
Atractyloside (respiratory poison)
Endpoint study
#1: Li, L., Tang, L. Y., Man, Gene C. W., Yeung, Benson H. Y., Lau, Clara B. S., Leung, P. C., Wang, C. C. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage.. human reproduction, 2011, vol. 26, no. 12, p. 3280–3288. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
unspecified
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
5
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Gram/kilogram (G015A)
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Effect concentration:
3.54
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
decrease in fetal growth parameters, increase in post-implantation loss, increases in gestational duration, prenatal and post-natal mortality
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
reproductive toxicity
Endpoint study
#2: Li, L., Tang, L. Y., Man, Gene C. W., Yeung, Benson H. Y., Lau, Clara B. S., Leung, P. C., Wang, C. C. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage.. human reproduction, 2011, vol. 26, no. 12, p. 3280–3288. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
unspecified
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rabbit (as animal) (A057T)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
3
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Gram/kilogram (G015A)
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Effect concentration:
1.87
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Critical effect:
TERATOGENIC (TOX06A)
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Target tissue:
Muscle, Skeletal (TT055A)
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Effect description:
fetal resorption, hydrops fetalis and short ear anomaly (congenital malformations)
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
teratogenicity - congenital malformations
