EFSA Compendium of Botanicals

Draft - work in progress

Atractylodes japonica Koidz. ex Kitam.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 362
Number of processed references:: 2

Compositions

Endpoint Studies

#1: hepatotoxicity in mice fed root extract

Genotoxicity

Composition #1: Choi, Keun Han., Jeong, Seung Il., Lee, Jun Ho., Hwang, Byung Soon., Lee, Seoul., Choi, Bong Kyu., Jung, Kyu Yong. Acetylene compound isolated from Atractylodes japonica stimulates the contractility of rat distal colon via inhibiting the nitrergic-purinergic relaxation. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 134, no. 1, p. 104–110. DOI: 10.1016/j.jep.2010.11.059. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

(6E, 12E)-tetradecadiene-8,10-diyne-1,3-diol ; (6E, 12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

polyacetylene derivatives (root)

Endpoint study #1: Sung, Hye-Young., Cho, Sung-Hee., Choi, Young-Sun., Lee, Hyang-Rim., Choi, Sang-Won. Effects of Methanol Extracts of Rubus Coreanus Miquel and Atractylodes Japonica Koidzumi on Hepatic Toxicity and Immunomodulating Activity in Mice . nutritional sciences, 2006, vol. 9, no. 2, p. 68–73. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

MeOH
Type of toxicological test:

short-term toxicity (CHD017TT)
Limit test:

Not applicable
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

30.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes, plain diet
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Percent (G138A)
Effect concentration:

5
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

elevated liver weight, elevated AST-level
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

hepatotoxicity in mice fed root extract