Draft - work in progress
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- Astracantha gummifera (Labill.) Podlech. // Astragalus gummifer Labill.
Astracantha gummifera (Labill.) Podlech. // Astragalus gummifer Labill.
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 50
- Number of processed references:
- 2
Composition #1: Yusufoglu, H. S., Alam, A. Isolation of Astragaloside IV and Cyclocephaloside I from Astragalus gummifera and evaluation of Astragaloside IV ON CCL4 induced liver damage in rats. PLANTA MEDICA, 2014, vol. 80, no. 10, p. 799–799. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
astragaloside IV (RF-00011262-PAR)
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Additional substance description:
saponin
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
astragaloside IV (saponin)
Endpoint study
#1: Hassan, Hazem M. M. Inhibitory activities of some mucilages and gums against certain intestinal disaccharidases.. Australian Journal of Basic and Applied Sciences, 2009, vol. 3, no. 3, p. 2741–2746. .
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Study relevance:
Human health
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Preparation/Extraction method:
Gum (as part-nature) (A166R)
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Type of toxicological test:
in vitro (CHD061TT)
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Limit test:
Not applicable
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
OTHER (OECD0PL)
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Unit of exposure duration:
Minute (G074A)
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Endpoint measured:
Half maximal inhibitory concentration (CHD021EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
149
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
intestinal lactase inhibition
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
intestinal lactase inhibition
Endpoint study
#2: Hassan, Hazem M. M. Inhibitory activities of some mucilages and gums against certain intestinal disaccharidases.. Australian Journal of Basic and Applied Sciences, 2009, vol. 3, no. 3, p. 2741–2746. .
-
Study relevance:
Human health
-
Preparation/Extraction method:
Gum (as part-nature) (A166R)
-
Type of toxicological test:
in vitro (CHD061TT)
-
Limit test:
Not applicable
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
OTHER (OECD0PL)
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-
Unit of exposure duration:
Minute (G074A)
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Endpoint measured:
Half maximal inhibitory concentration (CHD021EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
406
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
intestinal invertase inhibition
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
intestinal invertase inhibition
Endpoint study
#3: Hassan, Hazem M. M. Inhibitory activities of some mucilages and gums against certain intestinal disaccharidases.. Australian Journal of Basic and Applied Sciences, 2009, vol. 3, no. 3, p. 2741–2746. .
-
Study relevance:
Human health
-
Preparation/Extraction method:
Gum (as part-nature) (A166R)
-
Type of toxicological test:
in vitro (CHD061TT)
-
Limit test:
Not applicable
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Wistar (CHD013ST)
-
-
Route of exposure:
OTHER (OECD0PL)
-
-
Unit of exposure duration:
Minute (G074A)
-
Endpoint measured:
Half maximal inhibitory concentration (CHD021EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
506
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
intestinal maltase inhibition
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
intestinal maltase inhibition
