EFSA Compendium of Botanicals

Draft - work in progress

Aster tataricus L.f.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 298
Number of processed references:: 5

Compositions

#1: emodin (root) #2: chrysophanol (root) #3: physcion (root) #4: Aster saponins in roots #5: scopoletin #6: cyclic pentapeptides (e.g. astin C) #7: Triterpene saponins (root)

Endpoint Studies

#1: Hepatic injury

Genotoxicity

Composition #1: Wang Guo-yan., Wu Tao., Lin Ping-chuan., Chou Gui-xin., Wang Zheng-tao. Phenolic compounds isolated from rhizoma of Aster tataricus. zhongguo zhongyao zazhi, 2003, vol. 28, no. 10, p. 946–948. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

emodin (root)

Composition #2: Wang Guo-yan., Wu Tao., Lin Ping-chuan., Chou Gui-xin., Wang Zheng-tao. Phenolic compounds isolated from rhizoma of Aster tataricus. zhongguo zhongyao zazhi, 2003, vol. 28, no. 10, p. 946–948. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

chrysophanol (root)

Composition #3: Wang Guo-yan., Wu Tao., Lin Ping-chuan., Chou Gui-xin., Wang Zheng-tao. Phenolic compounds isolated from rhizoma of Aster tataricus. zhongguo zhongyao zazhi, 2003, vol. 28, no. 10, p. 946–948. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

physcion (root)

Composition #4: Nagao, Tsuneatsu., Hachiyama, Shizuko., Okabe, Hikaru., Yamauchi, Tatsuo. Studies on the constituents of Aster tataricus L.f. II. Structures of aster saponins isolated from the root.. Chemical & Pharmaceutical Bulletin, 1989, vol. 37, no. 8, p. 1977–83. DOI: 10.1248/cpb.37.1977. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Aster saponins
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aster saponins in roots

Composition #5: Lu, Yanhua., Wang, Zhengtao., Xu, Luoshan., Wu, Zibin. Polyphenolic compounds from Aster tataricus.. zhongcaoyao, 2002, vol. 33, no. 1, p. 17–18. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

Unspecified
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Composition #6: Liu, Xiaodong., Cao, Peipei., Zhang, Chaofeng., Xu, Xianghong., Zhang, Mian. Screening and analyzing potential hepatotoxic compounds in the ethanol extract of Asteris Radix by HPLC/DAD/ESI-MSn technique. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, vol. 67-68, p. 51–62. DOI: 10.1016/j.jpba.2012.04.034. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Cyclic pentapeptides Cyclic pentapeptides (RF-00010842-PAR)
Additional substance description:

e.g. astin C
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD and LC–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cyclic pentapeptides (e.g. astin C)

Composition #7: Zhao, Dong-Xia., Hu, Bing-Qiang., Zhang, Mian., Zhang, Chao-Feng., Xu, Xiang-Hong. Simultaneous separation and determination of phenolic acids, pentapeptides, and triterpenoid saponins in the root of Aster tataricus by high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry. JOURNAL OF SEPARATION SCIENCE, 2015, vol. 38, no. 4, p. 571–575. DOI: 10.1002/jssc.201401008. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH(50%)
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

Astersaponin A, C
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins (root)

Endpoint study #1: Liu, Xiaodong., Cao, Peipei., Zhang, Chaofeng., Xu, Xianghong., Zhang, Mian. Screening and analyzing potential hepatotoxic compounds in the ethanol extract of Asteris Radix by HPLC/DAD/ESI-MSn technique. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, vol. 67-68, p. 51–62. DOI: 10.1016/j.jpba.2012.04.034. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

EtOH extract (90%)
Type of toxicological test:

short-term toxicity (CHD017TT)
Limit test:

Not applicable
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

50
Control groups used:

yes
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Hepatic injury assessed by biochemical parameters and histopathological examination
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatic injury