EFSA Compendium of Botanicals

Draft - work in progress

Asclepias curassavica L. (as plant) // Asclepias currassavica L.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 326
Number of processed references:: 7

Compositions

#1: alkaloids #2: 12-O-benzoylsarcostin #3: 12-O-benzoyldeacylmetaplexigenin #4: Taylorons, acyl-pregnane derivatves #5: Kidjolanin, acyl-pregnane derivative #6: Calactins (cardenolides) #7: Uscharin (cardenolides) #8: Pregnane derivatives #9: Calactinic acid methyl ester (cardenolides) #10: Curassavosides A-F #11: 12-O-Benzoylsarcostin #12: 12-O-benzoyldeacylmetaplexigenin #13: coroglaucigenin (coroglaucigenins) #14: calotropagenin (calotropins) #15: desglucouzarin (desglucouzarins) #16: uscharidin (cardenolides) #17: asclepin (asclepins) #18: Calotropins (cardenolides) #19: Coroglaucigenins (cardenolides) #20: Calotropins (cardenolides) #21: Ascleposide (asclepins) #22: Digitoxigenin (cardenolides) #23: Sarcostin (cardenolides) #24: Cardenolide lactates (cardenolides) #25: Curassavoside B (curassavosides) #26: frugoside (frugosides) #27: Gofrusides (cardenolides) #28: Frugosides (cardenolides)

Endpoint Studies

Genotoxicity

Composition #1: Demarco, Diego. Micromorphology and Histochemistry of the Laticifers from Vegetative Organs of Asclepiadoideae species (Apocynaceae). Acta Biologica Colombiana, 2015, vol. 20, no. 1, p. 57–65. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

Hystochemical methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #2: Warashina, Tsutomu., Noro, Tadataka. Steroidal glycosides from the roots of Asclepias curassavica.. Chemical & pharmaceutical bulletin, 2008, vol. 56, no. 3, p. 315–22. DOI: 10.1248/cpb.56.315. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Steroidal alkaloids (RF-00004336-PAR)
Additional substance description:

12-O-Benzoylsarcostin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.3
Internal remarks:

12-O-benzoylsarcostin

Composition #3: Warashina, Tsutomu., Noro, Tadataka. Steroidal glycosides from the roots of Asclepias curassavica.. Chemical & pharmaceutical bulletin, 2008, vol. 56, no. 3, p. 315–22. DOI: 10.1248/cpb.56.315. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

steroidal saponins (RF-00010818-PAR)
Additional substance description:

12-O-benzoyldeacylmetaplexigenin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>11.9
Internal remarks:

12-O-benzoyldeacylmetaplexigenin

Composition #4: Warashina, Tsutomu., Noro, Tadataka. Steroidal glycosides from the roots of Asclepias curassavica.. Chemical & pharmaceutical bulletin, 2008, vol. 56, no. 3, p. 315–22. DOI: 10.1248/cpb.56.315. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

pregnane derivatives (RF-00004313-PAR)
Additional substance description:

Taylorons
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Taylorons, acyl-pregnane derivatves

Composition #5: Warashina, Tsutomu., Noro, Tadataka. Steroidal glycosides from the roots of Asclepias curassavica.. Chemical & pharmaceutical bulletin, 2008, vol. 56, no. 3, p. 315–22. DOI: 10.1248/cpb.56.315. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Kidjolanin (RF-00011347-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>9.5
Internal remarks:

Kidjolanin, acyl-pregnane derivative

Composition #6: Roy, MC., Chang, FR., Huang, HC., Chiang, MYN., Wu, YC. Cytotoxic principles from the Formosan milkweed, Asclepias curassavica. JOURNAL OF NATURAL PRODUCTS, 2005, vol. 68, no. 10, p. 1494–1499. DOI: 10.1021/np0501740. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, partition EtOAc/H2O
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

Calactins
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calactins (cardenolides)

Composition #7: Roy, MC., Chang, FR., Huang, HC., Chiang, MYN., Wu, YC. Cytotoxic principles from the Formosan milkweed, Asclepias curassavica. JOURNAL OF NATURAL PRODUCTS, 2005, vol. 68, no. 10, p. 1494–1499. DOI: 10.1021/np0501740. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, partition EtOAc/H2O
Substance:

Uscharin (RF-00011132-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, MS
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.8
Internal remarks:

Uscharin (cardenolides)

Composition #8: Roy, MC., Chang, FR., Huang, HC., Chiang, MYN., Wu, YC. Cytotoxic principles from the Formosan milkweed, Asclepias curassavica. JOURNAL OF NATURAL PRODUCTS, 2005, vol. 68, no. 10, p. 1494–1499. DOI: 10.1021/np0501740. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, partition EtOAc/H2O
Substance:

pregnane derivatives (RF-00004313-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pregnane derivatives

Composition #9: Roy, MC., Chang, FR., Huang, HC., Chiang, MYN., Wu, YC. Cytotoxic principles from the Formosan milkweed, Asclepias curassavica. JOURNAL OF NATURAL PRODUCTS, 2005, vol. 68, no. 10, p. 1494–1499. DOI: 10.1021/np0501740. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, partition EtOAc/H2O
Substance:

Calactinic acid methyl ester (RF-00011420-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, MS
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>1.5
Internal remarks:

Calactinic acid methyl ester (cardenolides)

Composition #10: Li, Jun-Zhu., Liu, Hai-Yang., Lin, Yi-Ju., Hao, Xiao-Jiang., Ni, Wei., Chen, Chang-Xiang. Six new C(21) steroidal glycosides from Asclepias curassavica L.. STEROIDS, 2008, vol. 73, no. 6, p. 594–600. DOI: 10.1016/j.steroids.2008.01.015. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

Curassavosides A-F
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curassavosides A-F

Composition #11: Li, Jun-Zhu., Liu, Hai-Yang., Lin, Yi-Ju., Hao, Xiao-Jiang., Ni, Wei., Chen, Chang-Xiang. Six new C(21) steroidal glycosides from Asclepias curassavica L.. STEROIDS, 2008, vol. 73, no. 6, p. 594–600. DOI: 10.1016/j.steroids.2008.01.015. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

Steroidal alkaloids (RF-00004336-PAR)
Additional substance description:

12-O-Benzoylsarcostin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>4
Internal remarks:

12-O-Benzoylsarcostin

Composition #12: Li, Jun-Zhu., Liu, Hai-Yang., Lin, Yi-Ju., Hao, Xiao-Jiang., Ni, Wei., Chen, Chang-Xiang. Six new C(21) steroidal glycosides from Asclepias curassavica L.. STEROIDS, 2008, vol. 73, no. 6, p. 594–600. DOI: 10.1016/j.steroids.2008.01.015. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

steroidal saponins (RF-00010818-PAR)
Additional substance description:

12-O-benzoyldeacylmetaplexigenin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>6.9
Internal remarks:

12-O-benzoyldeacylmetaplexigenin

Composition #13: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% ethanol
Substance:

cannogenol (RF-00004192-PAR)
Additional substance description:

coroglaucigenin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16
Internal remarks:

coroglaucigenin (coroglaucigenins)

Composition #14: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% ethanol
Substance:

Calotropagenin (RF-00011134-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.6
Internal remarks:

calotropagenin (calotropins)

Composition #15: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% ethanol
Substance:

desglucouzarin (RF-00011277-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11
Internal remarks:

desglucouzarin (desglucouzarins)

Composition #16: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% ethanol
Substance:

uscharidin (RF-00011419-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31.4
Internal remarks:

uscharidin (cardenolides)

Composition #17: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

75% ethanol
Substance:

Asclepin (RF-00003700-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

17.4
Internal remarks:

asclepin (asclepins)

Composition #18: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

Calotropin (RF-00011271-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calotropins (cardenolides)

Composition #19: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

Coroglaucigenins
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coroglaucigenins (cardenolides)

Composition #20: Li, Jun-Zhu., Qing, Chen., Chen, Chang-Xiang., Hao, Xiao-Jiang., Liu, Hai-Yang. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, vol. 19, no. 7, p. 1956–1959. DOI: 10.1016/j.bmcl.2009.02.045. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 75%
Substance:

Calotropins (RF-00010794-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calotropins (cardenolides)

Composition #21: Zhang, Rong-Rong., Tian, Hai-Yan., Tan, Ya-Fang., Chung, Tse-Yu., Sun, Xiao-Hui., Xia, Xue., Ye, Wen-Cai., Middleton, David A., Fedosova, Natalya., Esmann, Mikael., Tzen, Jason T. C., Jiang, Ren-Wang. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, vol. 12, no. 44, p. 8919–8929. DOI: 10.1039/c4ob01545b. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70% (V/V) at 90 °C; partition EtOAc/H2O
Substance:

Ascleposide (RF-00011276-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MS, 1D- and 2D-NMR
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Ascleposide (asclepins)

Composition #22: Zhang, Rong-Rong., Tian, Hai-Yan., Tan, Ya-Fang., Chung, Tse-Yu., Sun, Xiao-Hui., Xia, Xue., Ye, Wen-Cai., Middleton, David A., Fedosova, Natalya., Esmann, Mikael., Tzen, Jason T. C., Jiang, Ren-Wang. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, vol. 12, no. 44, p. 8919–8929. DOI: 10.1039/c4ob01545b. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70% (V/V) at 90 °C; partition EtOAc/H2O
Substance:

digitoxigenin (RF-00004273-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MS, 1D- and 2D-NMR
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>1.2
Internal remarks:

Digitoxigenin (cardenolides)

Composition #23: Zhang, Rong-Rong., Tian, Hai-Yan., Tan, Ya-Fang., Chung, Tse-Yu., Sun, Xiao-Hui., Xia, Xue., Ye, Wen-Cai., Middleton, David A., Fedosova, Natalya., Esmann, Mikael., Tzen, Jason T. C., Jiang, Ren-Wang. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, vol. 12, no. 44, p. 8919–8929. DOI: 10.1039/c4ob01545b. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70% (V/V) at 90 °C; partition EtOAc/H2O
Substance:

Sarcostin (RF-00011133-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MS, 1D- and 2D-NMR
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

>1.0
Internal remarks:

Sarcostin (cardenolides)

Composition #24: Zhang, Rong-Rong., Tian, Hai-Yan., Tan, Ya-Fang., Chung, Tse-Yu., Sun, Xiao-Hui., Xia, Xue., Ye, Wen-Cai., Middleton, David A., Fedosova, Natalya., Esmann, Mikael., Tzen, Jason T. C., Jiang, Ren-Wang. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, vol. 12, no. 44, p. 8919–8929. DOI: 10.1039/c4ob01545b. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70% (V/V) at 90 °C; partition EtOAc/H2O
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

Cardenolide lactates
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MS, 1D- and 2D-NMR + X rays
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardenolide lactates (cardenolides)

Composition #25: Zhang, Rong-Rong., Tian, Hai-Yan., Tan, Ya-Fang., Chung, Tse-Yu., Sun, Xiao-Hui., Xia, Xue., Ye, Wen-Cai., Middleton, David A., Fedosova, Natalya., Esmann, Mikael., Tzen, Jason T. C., Jiang, Ren-Wang. Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, vol. 12, no. 44, p. 8919–8929. DOI: 10.1039/c4ob01545b. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70% (V/V) at 90 °C; partition EtOAc/H2O
Substance:

Curassavoside B (RF-00011457-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MS, 1D- and 2D-NMR
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.0
Internal remarks:

Curassavoside B (curassavosides)

Composition #26: ABE, F., MORI, Y., YAMAUCHI, T. CARDENOLIDE GLYCOSIDES FROM THE SEEDS OF ASCLEPIAS-CURASSAVICA. CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, vol. 40, no. 11, p. 2917–2920. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane/methanol/methanol:water
Substance:

frugosid (RF-00004296-PAR)
Additional substance description:

frugoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.162
Internal remarks:

frugoside (frugosides)

Composition #27: ABE, F., MORI, Y., YAMAUCHI, T. CARDENOLIDE GLYCOSIDES FROM THE SEEDS OF ASCLEPIAS-CURASSAVICA. CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, vol. 40, no. 11, p. 2917–2920. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane/methanol/methanol:water
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

Gofrusides
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gofrusides (cardenolides)

Composition #28: ABE, F., MORI, Y., YAMAUCHI, T. CARDENOLIDE GLYCOSIDES FROM THE SEEDS OF ASCLEPIAS-CURASSAVICA. CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, vol. 40, no. 11, p. 2917–2920. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane/methanol/methanol:water
Substance:

Frugosides (RF-00010793-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Frugosides (cardenolides)