EFSA Compendium of Botanicals

Draft - work in progress

Artemisia verlotiorum Lamotte

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 68
Number of processed references:: 5

Compositions

#1: Sesquiterpene lactones #2: 1,8-cineole #3: alpha-thujone (leaves ess oid) #4: beta-thujone #5: camphor #6: 1.8-cineole #7: alpha-thujone (aerial parts ess oil) #8: beta-thujone #9: camphor #10: carvone (aerial parts ess oil)

Endpoint Studies

Genotoxicity

#1: tested on allium cepa cells

Composition #1: Geissman, Theodore A. Sesquiterpene lactones of Artemisia. Artemisia verlotorum and Artemisia vulgaris.. Phytochemistry (Elsevier), 1970, vol. 9, no. 11, p. 2377–81. DOI: 10.1016/S0031-9422(00)85743-X. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform with further modifications
Substance:

sesquiterpene alkaloids (RF-00004371-PAR)
Additional substance description:

anhydroverlotorin, verlotorin, artemorin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #2: Vernin, GA. GC/MS analysis of Artemisia verlotiorum Lamotte oil. journal of essential oil research, 2000, vol. 12, no. 2, p. 143–146. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21
Internal remarks:

1,8-cineole

Composition #3: Vernin, GA. GC/MS analysis of Artemisia verlotiorum Lamotte oil. journal of essential oil research, 2000, vol. 12, no. 2, p. 143–146. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

47
Internal remarks:

alpha-thujone (leaves ess oid)

Composition #4: Vernin, GA. GC/MS analysis of Artemisia verlotiorum Lamotte oil. journal of essential oil research, 2000, vol. 12, no. 2, p. 143–146. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10
Internal remarks:

beta-thujone

Composition #5: Vernin, GA. GC/MS analysis of Artemisia verlotiorum Lamotte oil. journal of essential oil research, 2000, vol. 12, no. 2, p. 143–146. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1
Internal remarks:

camphor

Composition #6: Chericoni, S., Flamini, G., Campeol, E., Cioni, PL., Morelli, I. GC-MS analyses of the essential oil from the aerial parts of Artemisia verlotiorum: variability during the year . biochemical systematics and ecology, 2004, vol. 32, no. 4, p. 423–429. DOI: 10.1016/j.bse.2003.10.002. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.8-31.6
Internal remarks:

1.8-cineole

Composition #7: Chericoni, S., Flamini, G., Campeol, E., Cioni, PL., Morelli, I. GC-MS analyses of the essential oil from the aerial parts of Artemisia verlotiorum: variability during the year . biochemical systematics and ecology, 2004, vol. 32, no. 4, p. 423–429. DOI: 10.1016/j.bse.2003.10.002. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3-8.0
Internal remarks:

alpha-thujone (aerial parts ess oil)

Composition #8: Chericoni, S., Flamini, G., Campeol, E., Cioni, PL., Morelli, I. GC-MS analyses of the essential oil from the aerial parts of Artemisia verlotiorum: variability during the year . biochemical systematics and ecology, 2004, vol. 32, no. 4, p. 423–429. DOI: 10.1016/j.bse.2003.10.002. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.3-14.7
Internal remarks:

beta-thujone

Composition #9: Chericoni, S., Flamini, G., Campeol, E., Cioni, PL., Morelli, I. GC-MS analyses of the essential oil from the aerial parts of Artemisia verlotiorum: variability during the year . biochemical systematics and ecology, 2004, vol. 32, no. 4, p. 423–429. DOI: 10.1016/j.bse.2003.10.002. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.6-8.3
Internal remarks:

camphor

Composition #10: Juteau, F., Masotti, V., Viano, J., Bessiere, JM. Chemical variation in the oil of Artemisia verlotiorum Lamotte of French origin harvested at a vegetative stage and during flowering . journal of essential oil research, 2005, vol. 17, no. 3, p. 254–256. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1
Internal remarks:

carvone (aerial parts ess oil)

Genotox #1: de Souza, L.F.B., Laughinghouse IV, H.D., Pastori, T., Tedesco, M., Kuhn, A.W., do Canto-Dorow, T.S., Tedesco, S.B. Genotoxic potential of aqueous extracts of Artemisia verlotorum on the cell cycle of Allium cepa. International Journal of Environmental Studies, 2010, vol. 67, no. 6, p. 871–877. DOI: 10.1080/00207233.2010.520457. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

chromosome aberration assay (CHD047TT)
Method type:

in vitro
Guideline used:

According to
Guideline:

OTHER GUIDELINE (OECD2246PL)
Tested organism:

Other (A07XE)
Strain of test organism:

Root tip cells – Allium cepa (CHD173ST)
Route of exposure:

OTHER (OECD0PL)
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

antiproliferative activity, chromosomal aberations including brakes, bridges and disorganised bridges at 6;32;48 g/l in vitro
Internal remarks:

tested on allium cepa cells
Internal ID:

eid=2-s2.0-78650045920