EFSA Compendium of Botanicals

Draft - work in progress

Artemisia apiacea Hance

Family:: Compositae (Asteraceae)
Approval state:: Approved
Number of articles retrieved:: 81
Number of processed references:: 8

Compositions

#1: Artemisia ketone #2: 1,8-cineole #3: alpha-thujone #4: 1,8-cineole (ess oil) #5: artemisinin #6: Hydroxycoumarins #7: scopoletin #8: artemicapin C #9: herniarin #10: daphnetin dimethyl ether

Endpoint Studies

#1: alpha-Glucosidase inhibition - methanol extract

Genotoxicity

Composition #1: Yano, Katsumi. Mono- and sesqui-terpenes of the essential oils from Artemisia japonica and Artemisia apiacea.. flavour industry, 1970, vol. 1, no. 5, p. 328–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

artemisia ketone (RF-00004157-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Artemisia ketone

Composition #2: Yano, Katsumi. Mono- and sesqui-terpenes of the essential oils from Artemisia japonica and Artemisia apiacea.. flavour industry, 1970, vol. 1, no. 5, p. 328–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

1,8-cineole

Composition #3: Yano, Katsumi. Mono- and sesqui-terpenes of the essential oils from Artemisia japonica and Artemisia apiacea.. flavour industry, 1970, vol. 1, no. 5, p. 328–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alpha-thujone

Composition #4: Zhao, Lijuan., Xin, Guang., Zhang, Jieli. Volatile constituents of Artemisia apiacea Hance from Lulong Area in Hebei Province by gas chromatography-mass spectrometry.. shizhen guoyi guoyao, 2006, vol. 17, no. 9, p. 1691–1692. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

direct distillation DDE
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7
Internal remarks:

1,8-cineole (ess oil)

Composition #5: Tu, Youyou. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).. angewandte chemie, international edition, 2016, vol. 55, no. 35, p. 10210–10226. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

artemisinin (RF-00003658-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

artemisinin

Composition #6: Shimomura, H., Sashida, Y., Ohshima, Y. The Chemical Components of Artemisia apiacea Hance. II. More Coumarins from the Flower Heads. Chemical and Pharmaceutical Bulletin, 1980, vol. 28, no. 1, p. 347–348. DOI: 10.1248/cpb.28.347. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extract
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

hydroxycoumarins
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroxycoumarins

Composition #7: Kim, KS., Lee, S., Shin, JS., Shim, SH., Kim, BK. Arterninin, a new coumarin from Artemisia apiacea. FITOTERAPIA, 2002, vol. 73, no. 3, p. 266–268. DOI: 10.1016/S0367-326X(02)00070-9. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Composition #8: Lee, S., Kim, KS., Jang, JM., Park, Y., Kim, YB., Kim, BK. Phytochemical constituents from the herba of Artemisia apiacea. ARCHIVES OF PHARMACAL RESEARCH, 2002, vol. 25, no. 3, p. 285–288. DOI: 10.1007/BF02976627. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

artemicapin C (RF-00010992-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

artemicapin C

Composition #9: SHIMOMURA, H., SASHIDA, Y., OHSHIMA, Y. CHEMICAL-COMPONENTS OF ARTEMISIA-APIACEA .1. COUMARINS FROM ARTEMISIA-APIACEA. PHYTOCHEMISTRY, 1979, vol. 18, no. 10, p. 1761–1762. DOI: 10.1016/0031-9422(79)80212-5. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

herniarin (RF-00010991-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

herniarin

Composition #10: SHIMOMURA, H., SASHIDA, Y., OHSHIMA, Y. CHEMICAL-COMPONENTS OF ARTEMISIA-APIACEA .1. COUMARINS FROM ARTEMISIA-APIACEA. PHYTOCHEMISTRY, 1979, vol. 18, no. 10, p. 1761–1762. DOI: 10.1016/0031-9422(79)80212-5. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

daphnetin dimethyl ether (RF-00010990-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daphnetin dimethyl ether

Endpoint study #1: Nurul Islam, Md., Jung, Hyun Ah., Sohn, Hee Sook., Kim, Hye Mi., Choi, Jae Sue. Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.. Archives of Pharmacal Research, 2013, vol. 36, no. 5, p. 542–552. DOI: 10.1007/s12272-013-0069-7. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol extract
Type of toxicological test:

in vitro (CHD061TT)
Limit test:

Not applicable
Route of exposure:

OTHER (OECD0PL)
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

250
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-Glucosidase inhibition (57.57 ± 0.48 %)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-Glucosidase inhibition - methanol extract