EFSA Compendium of Botanicals

Draft - work in progress

Artemisia capillaris Thunb.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 1297
Number of processed references:: 6

Compositions

#1: coumarins (artemicapin A,B,C and D) #2: acenaphthylene #3: scoparone (shoot) #4: 1,8-cineole #5: eugenol #6: coumarins

Endpoint Studies

#1: alpha-glucosidase inhibition

Genotoxicity

#1: chromosomal abberration on plant extract positive (IP injection) #2: micronucleus assay on plant extract positive - IP injection

Composition #1: Kostova, I., Raleva, S., Genova, P., Argirova, R. Recent advances in the discovery and development of plant-derived natural coumarins and their analogues as anti human immunodeficiency virus - Type 1 (HIV-1) agents. Biotechnology and Biotechnological Equipment, 2005, vol. 19, no. 1, p. 16–22. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

artemicapin A, B, C and D
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins (artemicapin A,B,C and D)

Composition #2: Yun, KyeongWon. Phytotoxicity and Volatile Monoterpenes of Leaves from Artemisia capillaris and Artemisia iwayomogi Used as Korean Herbal Injin. Journal of Ecology and Environment, 2009, vol. 32, no. 1, p. 9–12. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

pentane
Substance:

Acenaphthylene (RF-00000043-ORG)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

37.91
Internal remarks:

acenaphthylene

Composition #3: Jang, SI., Kim, YJ., Lee, WY., Kwak, KC., Baek, SH., Kwak, GB., Yun, YG., Kwon, TO., Chung, HT., Chai, KY. Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma plus LPS. ARCHIVES OF PHARMACAL RESEARCH, 2005, vol. 28, no. 2, p. 203–208. DOI: 10.1007/BF02977716. [DOI link]

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hot water
Substance:

scoparone (RF-00004047-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

CC, C and H NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scoparone (shoot)

Composition #4: Verma, R. S., Laiq-ur-Rahman., Verma, R. K., Chauhan, Amit., Singh, Anand., Chanotiya, C. S., Yadav, Anju., Singh, A. K., Kukreja, A. K., Khanuja, S. P. S. Essential Oil Composition of the Inflorescence of Artemisia capillaris Thunb. Collected at Different Stages of Flowering from Kumaon Region of Western Himalaya . journal of essential oil research, 2010, vol. 22, no. 4, p. 340–343. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=1.3
Internal remarks:

1,8-cineole

Composition #5: Verma, R. S., Laiq-ur-Rahman., Verma, R. K., Chauhan, Amit., Singh, Anand., Chanotiya, C. S., Yadav, Anju., Singh, A. K., Kukreja, A. K., Khanuja, S. P. S. Essential Oil Composition of the Inflorescence of Artemisia capillaris Thunb. Collected at Different Stages of Flowering from Kumaon Region of Western Himalaya . journal of essential oil research, 2010, vol. 22, no. 4, p. 340–343. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.3-15
Internal remarks:

eugenol

Composition #6: Islam, Md Nurul., Jung, Hyun Ah., Sohn, Hee Sook., Kim, Hye Mi., Choi, Jae Sue. Potent alpha-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris . archives of pharmacal research, 2013, vol. 36, no. 5, p. 542–552. DOI: 10.1007/s12272-013-0069-7. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

daphnetin, umbelliferone, 7-methoxycoumarin, 6-methoxyartemicapin C, esculetin, esculin, scopolin, isoscopolin, scoparone and scopoletin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins

Endpoint study #1: Islam, Md Nurul., Jung, Hyun Ah., Sohn, Hee Sook., Kim, Hye Mi., Choi, Jae Sue. Potent alpha-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris . archives of pharmacal research, 2013, vol. 36, no. 5, p. 542–552. DOI: 10.1007/s12272-013-0069-7. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

250
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibitory activity (64.67%)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition

Genotox #1: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .

Study category:

Genotoxicity
Type of toxicological test:

chromosome aberration assay (CHD047TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male/Female
Exogenous metabolic activation applied:

not applicable
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

60
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

water extract of Artemisia capillaris - IP injection
Internal remarks:

chromosomal abberration on plant extract positive (IP injection)
Internal ID:

WOS:A1991FK36700010

Genotox #2: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male/Female
Exogenous metabolic activation applied:

not applicable
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

60
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

water extract of Artemisia capillaris - IP injection
Internal remarks:

micronucleus assay on plant extract positive - IP injection
Internal ID:

WOS:A1991FK36700010