Draft - work in progress
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- Artemisia capillaris Thunb.
Artemisia capillaris Thunb.
- Family:
- Asteraceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1297
- Number of processed references:
- 6
Composition #1: Kostova, I., Raleva, S., Genova, P., Argirova, R. Recent advances in the discovery and development of plant-derived natural coumarins and their analogues as anti human immunodeficiency virus - Type 1 (HIV-1) agents. Biotechnology and Biotechnological Equipment, 2005, vol. 19, no. 1, p. 16–22. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
artemicapin A, B, C and D
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
coumarins (artemicapin A,B,C and D)
Composition #2: Yun, KyeongWon. Phytotoxicity and Volatile Monoterpenes of Leaves from Artemisia capillaris and Artemisia iwayomogi Used as Korean Herbal Injin. Journal of Ecology and Environment, 2009, vol. 32, no. 1, p. 9–12. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
pentane
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Substance:
Acenaphthylene (RF-00000043-ORG)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
37.91
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Internal remarks:
acenaphthylene
Composition #3: Jang, SI., Kim, YJ., Lee, WY., Kwak, KC., Baek, SH., Kwak, GB., Yun, YG., Kwon, TO., Chung, HT., Chai, KY. Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma plus LPS. ARCHIVES OF PHARMACAL RESEARCH, 2005, vol. 28, no. 2, p. 203–208. DOI: 10.1007/BF02977716.
[
DOI link]
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Plant part:
Shoot (as part-nature) (A067T)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hot water
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Substance:
scoparone (RF-00004047-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
CC, C and H NMR, MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
scoparone (shoot)
Composition #4: Verma, R. S., Laiq-ur-Rahman., Verma, R. K., Chauhan, Amit., Singh, Anand., Chanotiya, C. S., Yadav, Anju., Singh, A. K., Kukreja, A. K., Khanuja, S. P. S. Essential Oil Composition of the Inflorescence of Artemisia capillaris Thunb. Collected at Different Stages of Flowering from Kumaon Region of Western Himalaya . journal of essential oil research, 2010, vol. 22, no. 4, p. 340–343. .
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
hydrodistillation
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Substance:
1,8-cineole (RF-00003470-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<=1.3
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Internal remarks:
1,8-cineole
Composition #5: Verma, R. S., Laiq-ur-Rahman., Verma, R. K., Chauhan, Amit., Singh, Anand., Chanotiya, C. S., Yadav, Anju., Singh, A. K., Kukreja, A. K., Khanuja, S. P. S. Essential Oil Composition of the Inflorescence of Artemisia capillaris Thunb. Collected at Different Stages of Flowering from Kumaon Region of Western Himalaya . journal of essential oil research, 2010, vol. 22, no. 4, p. 340–343. .
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
hydrodistillation
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Substance:
Eugenol (RF-00003807-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
4.3-15
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Internal remarks:
eugenol
Composition #6: Islam, Md Nurul., Jung, Hyun Ah., Sohn, Hee Sook., Kim, Hye Mi., Choi, Jae Sue. Potent alpha-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris . archives of pharmacal research, 2013, vol. 36, no. 5, p. 542–552. DOI: 10.1007/s12272-013-0069-7.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
daphnetin, umbelliferone, 7-methoxycoumarin, 6-methoxyartemicapin C, esculetin, esculin, scopolin, isoscopolin, scoparone and scopoletin
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
coumarins
Endpoint study
#1: Islam, Md Nurul., Jung, Hyun Ah., Sohn, Hee Sook., Kim, Hye Mi., Choi, Jae Sue. Potent alpha-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris . archives of pharmacal research, 2013, vol. 36, no. 5, p. 542–552. DOI: 10.1007/s12272-013-0069-7.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanol extract
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Type of toxicological test:
in vitro (CHD061TT)
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
250
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
alpha-glucosidase inhibitory activity (64.67%)
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
alpha-glucosidase inhibition
Genotox #1: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .
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Study category:
Genotoxicity
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Type of toxicological test:
chromosome aberration assay (CHD047TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Exogenous metabolic activation applied:
not applicable
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Route of exposure:
OTHER (OECD0PL)
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Number of organisms dosed:
60
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Endpoint measured:
chromosome aberration
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Remarks on genotox study:
water extract of Artemisia capillaris - IP injection
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Internal remarks:
chromosomal abberration on plant extract positive (IP injection)
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Internal ID:
WOS:A1991FK36700010
Genotox #2: YIN, XJ., LIU, DX., WANG, HC., ZHOU, Y. A STUDY ON THE MUTAGENICITY OF 102 RAW PHARMACEUTICALS USED IN CHINESE TRADITIONAL MEDICINE . mutation research, 1991, vol. 260, no. 1, p. 73–82. .
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Study category:
Genotoxicity
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Type of toxicological test:
micronucleus assay (CHD051TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Exogenous metabolic activation applied:
not applicable
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Route of exposure:
OTHER (OECD0PL)
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Number of organisms dosed:
60
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
water extract of Artemisia capillaris - IP injection
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Internal remarks:
micronucleus assay on plant extract positive - IP injection
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Internal ID:
WOS:A1991FK36700010