EFSA Compendium of Botanicals

Draft - work in progress

Artemisia argyi H.Lév. & Vaniot

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 834
Number of processed references:: 8

Endpoint Studies

Genotoxicity

#1: positive micronucleus assay #2: teratospermia, sperm deformation, with ess oil to male mice by gavage

Composition #1: Wen, Fuji., Yoo, Kyungseun., Eom, Minseop. Chemical composition of essential oil of Artemisia argyi.. xiangliao xiangjing huazhuangpin, 2007, no. 3, p. 21–23. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.32-26.12
Internal remarks:

1,8-cineole (quantified)

Composition #2: Wen, Fuji., Yoo, Kyungseun., Eom, Minseop. Chemical composition of essential oil of Artemisia argyi.. xiangliao xiangjing huazhuangpin, 2007, no. 3, p. 21–23. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.66-14.97
Internal remarks:

camphor (quantified)

Composition #3: Wen, Fuji., Yoo, Kyungseun., Eom, Minseop. Chemical composition of essential oil of Artemisia argyi.. xiangliao xiangjing huazhuangpin, 2007, no. 3, p. 21–23. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.32-3.60
Internal remarks:

alpha-thujone (quantified)

Composition #4: Wang, Yonglin., Liu, Laping. Analysis of the volatile constituents of Artemisia argyi by SPME/GC/MS.. xibei yaoxue zazhi, 2009, vol. 24, no. 5, p. 354–357. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

solid phase microextraction
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

49.09
Internal remarks:

1,8-cineole (quantitative)

Composition #5: Wang, Yonglin., Liu, Laping. Analysis of the volatile constituents of Artemisia argyi by SPME/GC/MS.. xibei yaoxue zazhi, 2009, vol. 24, no. 5, p. 354–357. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

solid phase microextraction
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.64
Internal remarks:

camphor (quantitative)

Composition #6: Lan, Meibing., Yu, Yongli., Li, Xiaohong. Analysis on chemical constituents of essential oil of Artemisia argyi Levl. et Vant. in Guizhou.. yaowu fenxi zazhi, 2009, vol. 29, no. 8, p. 1305–1308. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.22
Internal remarks:

1,8-cineole (quantitative)

Composition #7: Lan, Meibing., Yu, Yongli., Li, Xiaohong. Analysis on chemical constituents of essential oil of Artemisia argyi Levl. et Vant. in Guizhou.. yaowu fenxi zazhi, 2009, vol. 29, no. 8, p. 1305–1308. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

filifolone (RF-00011279-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.29
Internal remarks:

filifolone (quantitative)

Composition #8: Lan, Mei-bing., Yu, Yong-li., Lu, Wei., Liu, Mao-sheng., Zheng, Yan-fang., Yang, Hui-ying., Li, Xiao-hong. Chemical constituents and genotoxicity of volatile oil in Artemisia argyi from Gansu.. zhongguo shiyan fangjixue zazhi, 2012, vol. 18, no. 13, p. 252–255. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.45
Internal remarks:

1,8-cineole (quantified)

Composition #9: Lan, Mei-bing., Yu, Yong-li., Lu, Wei., Liu, Mao-sheng., Zheng, Yan-fang., Yang, Hui-ying., Li, Xiao-hong. Chemical constituents and genotoxicity of volatile oil in Artemisia argyi from Gansu.. zhongguo shiyan fangjixue zazhi, 2012, vol. 18, no. 13, p. 252–255. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.99
Internal remarks:

camphor (quantified)

Composition #10: Lan, Mei-bing., Yu, Yong-li., Lu, Wei., Liu, Mao-sheng., Zheng, Yan-fang., Yang, Hui-ying., Li, Xiao-hong. Chemical constituents and genotoxicity of volatile oil in Artemisia argyi from Gansu.. zhongguo shiyan fangjixue zazhi, 2012, vol. 18, no. 13, p. 252–255. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

artemisia ketone (RF-00004157-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.85
Internal remarks:

artemisia ketone (quantified)

Composition #11: Zhang, Shi-xian., Yu, Yong-hua., Ao, Ke-hou., Zeng, Qi-hua. GC-MS determination of components of volatile oil in Artemisia argyi.. lihua jianyan, huaxue fence, 2013, vol. 49, no. 6, p. 705–708. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22.19
Internal remarks:

1,8-cineole (quantitative)

Composition #12: Zhang, Shi-xian., Yu, Yong-hua., Ao, Ke-hou., Zeng, Qi-hua. GC-MS determination of components of volatile oil in Artemisia argyi.. lihua jianyan, huaxue fence, 2013, vol. 49, no. 6, p. 705–708. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.39
Internal remarks:

camphor (quantitative)

Composition #13: Zhang, Shi-xian., Yu, Yong-hua., Ao, Ke-hou., Zeng, Qi-hua. GC-MS determination of components of volatile oil in Artemisia argyi.. lihua jianyan, huaxue fence, 2013, vol. 49, no. 6, p. 705–708. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

artemisia ketone (RF-00004157-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.44
Internal remarks:

artemisia ketone (quantitative)

Composition #14: Zhang, Shi-xian., Yu, Yong-hua., Ao, Ke-hou., Zeng, Qi-hua. GC-MS determination of components of volatile oil in Artemisia argyi.. lihua jianyan, huaxue fence, 2013, vol. 49, no. 6, p. 705–708. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.26
Internal remarks:

eugenol (quantitative)

Composition #15: Zhao, Zhi-hong., Huang, Yong-yong., Zhang, Xiao-jun., Wang, Li-yang., Zhang, Zhuang-li., Wang, Gui-fang. GC-MS analysis of essential oil of artemisia argyi from Zhumadian in Henan Province.. zhengzhou daxue xuebao, lixueban, 2013, vol. 45, no. 2, p. 80–84. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

28.59
Internal remarks:

1,8-cineole (quantitative)

Composition #16: Zhao, Zhi-hong., Huang, Yong-yong., Zhang, Xiao-jun., Wang, Li-yang., Zhang, Zhuang-li., Wang, Gui-fang. GC-MS analysis of essential oil of artemisia argyi from Zhumadian in Henan Province.. zhengzhou daxue xuebao, lixueban, 2013, vol. 45, no. 2, p. 80–84. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.82
Internal remarks:

camphor (quantitative)

Composition #17: Hao, Peng-fei., Zhang, Li-fang., Zhang, Chao-yun., Huang, Xian-zhang. Comparative analysis GC-MS of Artemisiae Argyi Folium volatile oil extracted by SPME and SFE.. zhongguo shiyan fangjixue zazhi, 2014, vol. 20, no. 23, p. 68–71. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

super critical fluid extraction or solid phase microextraction
Substance:

artemisia ketone (RF-00004157-PAR)
Additional substance description:

isoartemisia ketone
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.15-12.15
Internal remarks:

isoartemisia ketone

Composition #18: Hao, Peng-fei., Zhang, Li-fang., Zhang, Chao-yun., Huang, Xian-zhang. Comparative analysis GC-MS of Artemisiae Argyi Folium volatile oil extracted by SPME and SFE.. zhongguo shiyan fangjixue zazhi, 2014, vol. 20, no. 23, p. 68–71. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

super critical fluid extraction or solid phase microextraction
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13.75-18.26
Internal remarks:

1.8-cineole

Composition #19: Adams, Michael., Efferth, Thomas., Bauer, Rudolf. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. PLANTA MEDICA, 2006, vol. 72, no. 9, p. 862–864. DOI: 10.1055/s-2006-947165. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Isoscopoletin (RF-00010985-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoscopoletin

Composition #20: Adams, Michael., Efferth, Thomas., Bauer, Rudolf. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. PLANTA MEDICA, 2006, vol. 72, no. 9, p. 862–864. DOI: 10.1055/s-2006-947165. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Genotox #1: Lan, Mei-bing., Yu, Yong-li., Lu, Wei., Liu, Mao-sheng., Zheng, Yan-fang., Yang, Hui-ying., Li, Xiao-hong. Chemical constituents and genotoxicity of volatile oil in Artemisia argyi from Gansu.. zhongguo shiyan fangjixue zazhi, 2012, vol. 18, no. 13, p. 252–255. .

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration for in vivo:

5.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

30
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

the micronucleus rates of bone marrow and fetal hepatic cell were all significantly increased at a oral dose of 2 mL·kg-1. Only the micronucleus rate on fetal liver was increased significantly with the oral dose of 1 mL·kg-1
Internal remarks:

positive micronucleus assay
Internal ID:

CAPLUS_AN_2012:1645750

Genotox #2: Lan, Mei-bing., Yu, Yong-li., Lu, Wei., Liu, Mao-sheng., Zheng, Yan-fang., Yang, Hui-ying., Li, Xiao-hong. Chemical constituents and genotoxicity of volatile oil in Artemisia argyi from Gansu.. zhongguo shiyan fangjixue zazhi, 2012, vol. 18, no. 13, p. 252–255. .

Study category:

Genotoxicity
Type of toxicological test:

other (CHD008TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Exogenous metabolic activation applied:

not applicable
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration for in vivo:

35.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

40
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

test on teratospermia of dosed males, 2 mL/kg bw positive
Internal remarks:

teratospermia, sperm deformation, with ess oil to male mice by gavage
Internal ID:

CAPLUS_AN_2012:1645750