EFSA Compendium of Botanicals

Draft - work in progress

Ardisia japonica (Thunb.) Blume

Family:: Primulaceae
Approval state:: Approved
Number of articles retrieved:: 248
Number of processed references:: 5

Compositions

#1: Embellin (benzoquinone) #2: Pentacyclic triterpene saponins: cyclamiretin A #3: chrysophanol (RF-00003737-PAR) (anthraquinone) #4: physcion (RF-00003993-PAR) (anthraquinone) #5: Pentacyclic triterpene saponins #6: Ardisianones A & B, maesanin (alkenyl-1,4-benzoquinones)

Endpoint Studies

Genotoxicity

Composition #1: Edderkaoui, Mouad., Lugea, Aurelia., Hui, Hongxiang., Eibl, Guido., Lu, Qing-Yi., Moro, Aune., Lu, Xuyang., Li, Gang., Go, Vay-Liang., Pandol, Stephen J. Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells.. nutrition and cancer, 2013, vol. 65, no. 8, p. 1232–1244. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

embelin (RF-00003797-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Embellin (benzoquinone)

Composition #2: De Tommasi, N., Piacente, S., De Simone, F., Pizza, C., Zhou, Z.L. Characterization of three new triterpenoid saponins from Ardisia japonica. journal of natural products, 1993, vol. 56, no. 10, p. 1669–1675. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether,chloroform and methanol
Substance:

pentacyclic triterpene glycosides pentacyclic triterpene glycosides (RF-00004328-PAR)
Additional substance description:

cyclamiretin A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins: cyclamiretin A

Composition #3: Li, YF., Hu, LH., Lou, FC., Li, J., Shen, Q. PTP1B inhibitors from Ardisia japonica. journal of asian natural products research, 2005, vol. 7, no. 1, p. 13–18. DOI: 10.1080/10286020310001596033. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extract
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

chrysophanol (RF-00003737-PAR) (anthraquinone)

Composition #4: Li, YF., Hu, LH., Lou, FC., Li, J., Shen, Q. PTP1B inhibitors from Ardisia japonica. journal of asian natural products research, 2005, vol. 7, no. 1, p. 13–18. DOI: 10.1080/10286020310001596033. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extract
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

physcion (RF-00003993-PAR) (anthraquinone)

Composition #5: Chang, Xiaolong., Li, Wei., Jia, Zhonghua., Satou, Tadaaki., Fushiya, Shinji., Koike, Kazuo. Biologically active triterpenoid saponins from Ardisia japonica. journal of natural products, 2007, vol. 70, no. 2, p. 179–187. DOI: 10.1021/np0604681. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Ardisianosides A to K; Ardisicrenolide A; Cyclamin; Ardisiacrispin B; Primularin; and Ardiisiamamillosides H, F, C and G.
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins

Composition #6: FUKUYAMA, Y., KIRIYAMA, Y., OKINO, J., KODAMA, M., IWAKI, H., HOSOZAWA, S., MATSUI, K. NATURALLY-OCCURRING 5-LIPOXYGENASE INHIBITOR .2. STRUCTURES AND SYNTHESES OF ARDISIANONE-A AND ARDISIANONE-B, AND MAESANIN, ALKENYL-1,4-BENZOQUINONES FROM THE RHIZOME OF ARDISIA-JAPONICA . chemical & pharmaceutical bulletin, 1993, vol. 41, no. 3, p. 561–565. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

benzoquinones (RF-00010840-PAR)
Additional substance description:

Ardisianones A & B, maesanin (alkenyl-1,4-benzoquinones)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ardisianones A & B, maesanin (alkenyl-1,4-benzoquinones)